Cited 12 times in
The Clinical Measures Associated with C-peptide Decline in Patients with Type 1 Diabetes over 15 Years
DC Field | Value | Language |
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dc.contributor.author | 권아름 | - |
dc.contributor.author | 김예진 | - |
dc.contributor.author | 김호성 | - |
dc.contributor.author | 채현욱 | - |
dc.date.accessioned | 2014-12-18T09:34:47Z | - |
dc.date.available | 2014-12-18T09:34:47Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88435 | - |
dc.description.abstract | This study was done to characterize the natural course of C-peptide levels in patients with type 1 diabetes and identify distinguishing characters among patients with lower rates of C-peptide decline. A sample of 95 children with type 1 diabetes was analyzed to retrospectively track serum levels of C-peptide, HbA1c, weight, BMI, and diabetic complications for the 15 yr after diagnosis. The clinical characteristics were compared between the patients with low and high C-peptide levels, respectively. The average C-peptide level among all patients was significantly reduced five years after diagnosis (P < 0.001). The incidence of diabetic ketoacidosis was significantly lower among the patients with high levels of C-peptide (P = 0.038). The body weight and BMI standard deviation scores (SDS) 15 yr after diagnosis were significantly higher among the patients with low C-peptide levels (weight SDS, P = 0.012; BMI SDS, P = 0.044). In conclusion, C-peptide level was significantly decreased after 5 yr from diagnosis. Type 1 diabetes patients whose beta-cell functions were preserved might have low incidence of diabetic ketoacidosis. The declines of C-peptide level after diagnosis in type 1 diabetes may be associated with changes of body weight and BMI. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Body Weight | - |
dc.subject.MESH | C-Peptide/blood* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Diabetes Complications | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/blood | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/diagnosis* | - |
dc.subject.MESH | Diabetic Ketoacidosis/epidemiology | - |
dc.subject.MESH | Diabetic Retinopathy/epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Glycated Hemoglobin A/analysis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Peripheral Nervous System Diseases/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | The Clinical Measures Associated with C-peptide Decline in Patients with Type 1 Diabetes over 15 Years | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Tae Ho Lee | - |
dc.contributor.googleauthor | Ah Reum Kwon | - |
dc.contributor.googleauthor | Ye Jin Kim | - |
dc.contributor.googleauthor | Hyun Wook Chae | - |
dc.contributor.googleauthor | Ho Seong Kim | - |
dc.contributor.googleauthor | Duk Hee Kim | - |
dc.identifier.doi | 10.3346/jkms.2013.28.9.1340 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00228 | - |
dc.contributor.localId | A00736 | - |
dc.contributor.localId | A01184 | - |
dc.contributor.localId | A04026 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 24015040 | - |
dc.subject.keyword | Body Mass Index | - |
dc.subject.keyword | Body Weight | - |
dc.subject.keyword | C-Peptide | - |
dc.subject.keyword | Diabetes Mellitus, Type 1 | - |
dc.subject.keyword | Diabetic Ketoacidosis | - |
dc.contributor.alternativeName | Kwon, Ah Reum | - |
dc.contributor.alternativeName | Kim, Ye Jin | - |
dc.contributor.alternativeName | Kim, Ho Seong | - |
dc.contributor.alternativeName | Chae, Hyun Wook | - |
dc.contributor.affiliatedAuthor | Kwon, Ah Reum | - |
dc.contributor.affiliatedAuthor | Kim, Ye Jin | - |
dc.contributor.affiliatedAuthor | Kim, Ho Seong | - |
dc.contributor.affiliatedAuthor | Chae, Hyun Wook | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 28 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1340 | - |
dc.citation.endPage | 1344 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.28(9) : 1340-1344, 2013 | - |
dc.identifier.rimsid | 34032 | - |
dc.type.rims | ART | - |
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