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Enlarged Cochlear Aqueducts: A Potential Route for CSF Gushers in Patients With Enlarged Vestibular Aqueducts

Authors
 Bo Gyung Kim  ;  Nam Suk Sim  ;  Sung Huhn Kim  ;  Un-Kyung Kim  ;  Soyeun Kim  ;  Jae Young Choi 
Citation
 OTOLOGY & NEUROTOLOGY, Vol.34(9) : 1660-1665, 2013 
Journal Title
 OTOLOGY & NEUROTOLOGY 
ISSN
 1531-7129 
Issue Date
2013
MeSH
Adolescent ; Adult ; Child ; Child, Preschool ; Cochlear Aqueduct/diagnostic imaging ; Cochlear Aqueduct/surgery* ; Cochlear Implantation/methods* ; Female ; Genetic Testing ; Hearing Loss, Sensorineural/diagnostic imaging ; Hearing Loss, Sensorineural/genetics ; Hearing Loss, Sensorineural/surgery* ; Humans ; Male ; Membrane Transport Proteins/genetics ; Radiography ; Retrospective Studies ; Treatment Outcome ; Vestibular Aqueduct/abnormalities* ; Vestibular Aqueduct/diagnostic imaging ; Vestibular Aqueduct/surgery
Keywords
Adolescent ; Adult ; Child ; Child, Preschool ; Cochlear Aqueduct/diagnostic imaging ; Cochlear Aqueduct/surgery* ; Cochlear Implantation/methods* ; Female ; Genetic Testing ; Hearing Loss, Sensorineural/diagnostic imaging ; Hearing Loss, Sensorineural/genetics ; Hearing Loss, Sensorineural/surgery* ; Humans ; Male ; Membrane Transport Proteins/genetics ; Radiography ; Retrospective Studies ; Treatment Outcome ; Vestibular Aqueduct/abnormalities* ; Vestibular Aqueduct/diagnostic imaging ; Vestibular Aqueduct/surgery
Abstract
OBJECTIVE: We investigated whether the size of the cochlear aqueduct (CA) is increased in patients with enlarged vestibular aqueducts (EVAs) compared with individuals with normal inner ear anatomy. Furthermore, we assessed whether the size of the CA is related to the cerebrospinal fluid (CSF) gusher during cochlear implantation (CI) surgery. STUDY DESIGN: Retrospective study. SETTING: Tertiary referral center. PATIENTS: The medical records for 35 patients with a biallelic SLC26A4 mutation were reviewed. All of the patients were confirmed to have EVA by temporal bone computed tomography (TBCT) and biallelic SLC26A4 mutation by genetic analysis. Thirty-six age- and sex-matched patients without a mutation in the SLC26A4 gene were selected as comparison group. MAIN OUTCOME MEASURES: The diameters of the CA and vestibular aqueduct (VA) were measured, and the type of CA was evaluated using TBCT. RESULTS: The CA was larger in patients with EVA (2.39 ± 0.99 mm) as compared with controls (1.76 ± 0.87 mm; p < 0.001). The types that could be most easily visualized from the subarachnoid space to the cochlea were more common in patients with EVA. Furthermore, mean CA size was significantly larger in EVA patients with CSF gushers (3.65 ± 1.12 mm) as compared with those without CSF gushers (2.03 ± 0.66 mm; p < 0.001). CONCLUSION: The CA is a potential pathway for CSF gushers between the subarachnoid space and the inner ear. Therefore, we suggest that evaluation of the CA by TBCT may be helpful in predicting intraoperative CSF gushers in patients with EVA.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00129492-201312000-00020&LSLINK=80&D=ovft
DOI
10.1097/MAO.0b013e3182a036e4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Bo Gyung(김보경)
Kim, Sung Huhn(김성헌)
Choi, Jae Young(최재영) ORCID logo https://orcid.org/0000-0001-9493-3458
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88414
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