4 68

Cited 5 times in

The role of critical shear stress on acute coronary syndrome.

Authors
 Jongyoun Kim ; Hyemoon Chung ; Sehyun Shin ; Ali Karimi ; Byoung-Kwon Lee ; Minhee Cho 
Citation
 Clinical Hemorheology and Microcirculation, Vol.55(1) : 101~109, 2013 
Journal Title
 Clinical Hemorheology and Microcirculation 
ISSN
 1386-0291 
Issue Date
2013
Abstract
Increased aggregation of RBC is associated with many vascular diseases, including acute coronary syndrome (ACS). Critical shear-stress (CSS) as in index of red cell aggregation is defined as either the minimum shear-stress required dispersing the aggregates. The objective of this study is to access the role of CSS in ACS comparing to SA, and to evaluate the correlation with usual biomarkers for atherosclerosis such as fibrinogen, hs-CRP. 169 SA and 223 ACS patients were finally enrolled. A detailed medical history and laboratory data were obtained for each participant from clinical records. CSS is measured by simultaneous measurement of shear stress and light backscattering using a small disposable kit with a microfluidic hemorheometer. We hypothesized that higher value of CSS might be associated increased thrombosis in ACS. As results, relatively younger age was shown and more male in ACS patients, and inflammatory markers (WBC, hs-CRP) were higher in ACS. Whole blood viscosities were significantly higher in ACS than SA along at all shear rates. CSS was 25.7% higher in ACS (333.8 ± 147.8) than in SA (265.4 ± 149.9 mPa) (p < 0.001). CSS was highly correlated white blood cell counts, hs-CRP, fibrinogen, and erythrocyte sedimentation rate (ESR). Among those variables, fibrinogen, and ESR were strongly correlated with CSS. We may suggest that CSS could be used as a novel risk marker for ACS.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88408
DOI
10.3233/CH-131694
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://iospress.metapress.com/content/w423163377l7555h/?genre=article&issn=1386-0291&volume=55&issue=1&spage=101
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse