4 298

Cited 11 times in

The role of critical shear stress on acute coronary syndrome.

DC FieldValueLanguage
dc.contributor.author김종윤-
dc.contributor.author이병권-
dc.contributor.author정혜문-
dc.date.accessioned2014-12-18T09:33:57Z-
dc.date.available2014-12-18T09:33:57Z-
dc.date.issued2013-
dc.identifier.issn1386-0291-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88408-
dc.description.abstractIncreased aggregation of RBC is associated with many vascular diseases, including acute coronary syndrome (ACS). Critical shear-stress (CSS) as in index of red cell aggregation is defined as either the minimum shear-stress required dispersing the aggregates. The objective of this study is to access the role of CSS in ACS comparing to SA, and to evaluate the correlation with usual biomarkers for atherosclerosis such as fibrinogen, hs-CRP. 169 SA and 223 ACS patients were finally enrolled. A detailed medical history and laboratory data were obtained for each participant from clinical records. CSS is measured by simultaneous measurement of shear stress and light backscattering using a small disposable kit with a microfluidic hemorheometer. We hypothesized that higher value of CSS might be associated increased thrombosis in ACS. As results, relatively younger age was shown and more male in ACS patients, and inflammatory markers (WBC, hs-CRP) were higher in ACS. Whole blood viscosities were significantly higher in ACS than SA along at all shear rates. CSS was 25.7% higher in ACS (333.8 ± 147.8) than in SA (265.4 ± 149.9 mPa) (p < 0.001). CSS was highly correlated white blood cell counts, hs-CRP, fibrinogen, and erythrocyte sedimentation rate (ESR). Among those variables, fibrinogen, and ESR were strongly correlated with CSS. We may suggest that CSS could be used as a novel risk marker for ACS.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCLINICAL HEMORHEOLOGY AND MICROCIRCULATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Coronary Syndrome/blood*-
dc.subject.MESHAngina, Unstable/blood-
dc.subject.MESHAtherosclerosis/blood-
dc.subject.MESHBiomechanical Phenomena-
dc.subject.MESHErythrocyte Aggregation/physiology*-
dc.subject.MESHFemale-
dc.subject.MESHHemorheology-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMyocardial Infarction/blood-
dc.subject.MESHStress, Mechanical-
dc.titleThe role of critical shear stress on acute coronary syndrome.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJongyoun Kim-
dc.contributor.googleauthorHyemoon Chung-
dc.contributor.googleauthorMinhee Cho-
dc.contributor.googleauthorByoung-Kwon Lee-
dc.contributor.googleauthorAli Karimi-
dc.contributor.googleauthorSehyun Shin-
dc.identifier.doi10.3233/CH-131694-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00926-
dc.contributor.localIdA02793-
dc.contributor.localIdA03779-
dc.relation.journalcodeJ00576-
dc.identifier.eissn1875-8622-
dc.identifier.pmid23445628-
dc.identifier.urlhttp://iospress.metapress.com/content/w423163377l7555h/?genre=article&issn=1386-0291&volume=55&issue=1&spage=101-
dc.subject.keywordCritical shear stress-
dc.subject.keywordRBC aggregation-
dc.subject.keywordacute coronary syndrome-
dc.contributor.alternativeNameKim, Jong Youn-
dc.contributor.alternativeNameLee, Byoung Kwon-
dc.contributor.alternativeNameChung, Hye Moon-
dc.contributor.affiliatedAuthorKim, Jong Youn-
dc.contributor.affiliatedAuthorLee, Byoung Kwon-
dc.contributor.affiliatedAuthorChung, Hye Moon-
dc.rights.accessRightsnot free-
dc.citation.volume55-
dc.citation.number1-
dc.citation.startPage101-
dc.citation.endPage109-
dc.identifier.bibliographicCitationCLINICAL HEMORHEOLOGY AND MICROCIRCULATION, Vol.55(1) : 101-109, 2013-
dc.identifier.rimsid32495-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.