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Clinicopathologic characteristics of STAT1 positive/interleukin-8 negative subgroup in triple negative breast cancer defined by surrogate immunohistochemistry

Authors
 Sewha Kim  ;  Do Hee Kim  ;  Woo-Hee Jung  ;  Ja Seung Koo 
Citation
 HISTOLOGY AND HISTOPATHOLOGY, Vol.28(11) : 1461-1471, 2013 
Journal Title
 HISTOLOGY AND HISTOPATHOLOGY 
ISSN
 0213-3911 
Issue Date
2013
MeSH
Biomarkers, Tumor/analysis ; Biomarkers, Tumor/immunology* ; Female ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Interleukin-8/biosynthesis ; Kaplan-Meier Estimate ; Middle Aged ; STAT1 Transcription Factor/biosynthesis ; Tissue Array Analysis ; Triple Negative Breast Neoplasms/classification* ; Triple Negative Breast Neoplasms/immunology* ; Triple Negative Breast Neoplasms/pathology*
Keywords
Breast cancer ; Immune ; Triple negative
Abstract
BACKGROUND: The aim of this study was to define immune-related triple negative breast cancer (TNBC) using immunohistochemistry for STAT1, CD20, CD3, IL-8, and IFN-γ and to assess its clinicopathologic characteristics. MATERIAL AND METHODS: Tissues from 133 cases of TNBC were used for a tissue microarray. Expression of STAT1, CD20, CD3, IL-8, and IFN-γ were evaluated by immunohistochemical staining of the tissue microarrays. Immune-related type was defined as TNBC which was positive for STAT1 and negative for IL-8. A separate assessment of IL-8 and STAT1 status in tumor and stroma compartment was used to further classify immune-related type into tumor-based and stroma-based immune-related TNBC. RESULTS: Stroma-based, immune-related TNBC showed a significantly smaller central acellular zone (p=0.043), more lymphocytic infiltration (p⟨0.001), higher CD20 index (p=0.001), and higher CD3 index (p=0.018) than stroma-based, non-immune-related TNBC. IL-8 was independently associated with shorter disease-free survival (Hazard ratio: 3.804, 95% CI: 1.234-11.729, p=0.020) and shorter overall survival (Hazard ratio: 3.434, 95% CI: 1.132-10.414, p=0.029). CONCLUSIONS: Immune-related proteins such as STAT1, IFN-γ, IL-8, and CD20 were variably expressed in TNBCs. Stroma-based, immune-related TNBC (when positive for stromal STAT1 and negative for stromal IL-8) showed significantly higher lymphocytic infiltration including both CD3 positive T cell and CD20 positive B cell.
Full Text
http://www.hh.um.es/Abstracts/Vol_28/28_11/28_11_1461.htm
DOI
10.14670/HH-28.1461
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Kim, Do Hee(김도희)
Jung, Woo Hee(정우희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88319
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