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Immunostimulatory Effects of Silica Nanoparticles in Human Monocytes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양은정 | - |
dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2014-12-18T09:28:14Z | - |
dc.date.available | 2014-12-18T09:28:14Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88229 | - |
dc.description.abstract | Amorphous silica particles, whose applications are increasing in many biomedical fields, are known to be less toxic than crystalline silica. In this study, the inflammatory effects of amorphous silica nanoparticles were investigated using 30-nm amorphous silica nanoparticles and human peripheral blood mononuclear cells (PBMCs) or purified monocytes. As a result, production of IL-1β and IL-8 were increased. In addition, the mitochondrial reactive oxygen species (ROS) was detected, which may lead to mitochondrial membrane disruption. Most importantly, inflammasome formation was observed. Therefore, these results provide immunological information about amorphous silica nanoparticles and suggest that amorphous silica nanoparticles can evoke innate immune reactions in human monocytes through production of IL-1β and IL-8. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korea Society for Immunology : Korean Society of Biological Response Modifiers | - |
dc.relation.isPartOf | IMMUNE NETWORK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Crystallins | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-8 | - |
dc.subject.MESH | Mitochondrial Membranes | - |
dc.subject.MESH | Monocytes | - |
dc.subject.MESH | Nanoparticles | - |
dc.subject.MESH | Reactive Oxygen Species | - |
dc.subject.MESH | Silicon Dioxide | - |
dc.title | Immunostimulatory Effects of Silica Nanoparticles in Human Monocytes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Eun-Jeoung Yang | - |
dc.contributor.googleauthor | In-Hong Choi | - |
dc.identifier.doi | 10.4110/in.2013.13.3.94 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02311 | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J01033 | - |
dc.identifier.eissn | 2092-6685 | - |
dc.identifier.pmid | 23885223 | - |
dc.subject.keyword | Cytokine | - |
dc.subject.keyword | Humanmonocytes | - |
dc.subject.keyword | Inflammasome | - |
dc.subject.keyword | Mitochondrial membrane | - |
dc.subject.keyword | Silicananoparticles | - |
dc.contributor.alternativeName | Yang, Eun Jeoung | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | Yang, Eun Jeoung | - |
dc.contributor.affiliatedAuthor | Choi, In Hong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 94 | - |
dc.citation.endPage | 101 | - |
dc.identifier.bibliographicCitation | IMMUNE NETWORK, Vol.13(3) : 94-101, 2013 | - |
dc.identifier.rimsid | 33138 | - |
dc.type.rims | ART | - |
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