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Cited 173 times in

Bacterial-Derived Uracil as a Modulator of Mucosal Immunity and Gut-Microbe Homeostasis in Drosophila

DC FieldValueLanguage
dc.contributor.author김민지-
dc.contributor.author유지환-
dc.date.accessioned2014-12-18T09:27:57Z-
dc.date.available2014-12-18T09:27:57Z-
dc.date.issued2013-
dc.identifier.issn0092-8674-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88220-
dc.description.abstractAll metazoan guts are subjected to immunologically unique conditions in which an efficient antimicrobial system operates to eliminate pathogens while tolerating symbiotic commensal microbiota. However, the molecular mechanisms controlling this process are only partially understood. Here, we show that bacterial-derived uracil acts as a ligand for dual oxidase (DUOX)-dependent reactive oxygen species generation in Drosophila gut and that the uracil production in bacteria causes inflammation in the gut. The acute and controlled uracil-induced immune response is required for efficient elimination of bacteria, intestinal cell repair, and host survival during infection of nonresident species. Among resident gut microbiota, uracil production is absent in symbionts, allowing harmonious colonization without DUOX activation, whereas uracil release from opportunistic pathobionts provokes chronic inflammation. These results reveal that bacteria with distinct abilities to activate uracil-induced gut inflammation, in terms of intensity and duration, act as critical factors that determine homeostasis or pathogenesis in gut-microbe interactions-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCELL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHDrosophila/immunology*-
dc.subject.MESHDrosophila/microbiology*-
dc.subject.MESHGastrointestinal Tract/immunology-
dc.subject.MESHGastrointestinal Tract/microbiology-
dc.subject.MESHGastrointestinal Tract/physiology-
dc.subject.MESHHomeostasis-
dc.subject.MESHHumans-
dc.subject.MESHImmunity,Mucosal*-
dc.subject.MESHInflammation/immunology-
dc.subject.MESHInflammation/microbiology-
dc.subject.MESHInflammatory Bowel Diseases/immunology-
dc.subject.MESHInflammatory Bowel Diseases/microbiology-
dc.subject.MESHNADPH Oxidases/metabolism-
dc.subject.MESHPectobacterium carotovorum/physiology*-
dc.subject.MESHReactive Oxygen Species/metabolism-
dc.subject.MESHStem Cells/metabolism-
dc.subject.MESHSymbiosis*-
dc.subject.MESHUracil/metabolism*-
dc.titleBacterial-Derived Uracil as a Modulator of Mucosal Immunity and Gut-Microbe Homeostasis in Drosophila-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.department생체방어연구센터-
dc.contributor.googleauthorKyung-Ah Lee-
dc.contributor.googleauthorSung-Hee Kim-
dc.contributor.googleauthorEun-Kyoung Kim-
dc.contributor.googleauthorEun-Mi Ha-
dc.contributor.googleauthorHyejin You-
dc.contributor.googleauthorBoram Kim-
dc.contributor.googleauthorMin-Ji Kim-
dc.contributor.googleauthorYoungjoo Kwon-
dc.contributor.googleauthorJi-Hwan Ryu-
dc.contributor.googleauthorWon-Jae Lee-
dc.identifier.doi10.1016/j.cell.2013.04.009-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00477-
dc.contributor.localIdA02522-
dc.relation.journalcodeJ00472-
dc.identifier.eissn1097-4172-
dc.identifier.pmid23663779-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0092867413004509-
dc.subject.keywordAnimals-
dc.subject.keywordDrosophila/immunology*-
dc.subject.keywordDrosophila/microbiology*-
dc.subject.keywordGastrointestinal Tract/immunology-
dc.subject.keywordGastrointestinal Tract/microbiology-
dc.subject.keywordGastrointestinal Tract/physiology-
dc.subject.keywordHomeostasis-
dc.subject.keywordHumans-
dc.subject.keywordImmunity,Mucosal*-
dc.subject.keywordInflammation/immunology-
dc.subject.keywordInflammation/microbiology-
dc.subject.keywordInflammatory Bowel Diseases/immunology-
dc.subject.keywordInflammatory Bowel Diseases/microbiology-
dc.subject.keywordNADPH Oxidases/metabolism-
dc.subject.keywordPectobacterium carotovorum/physiology*-
dc.subject.keywordReactive Oxygen Species/metabolism-
dc.subject.keywordStem Cells/metabolism-
dc.subject.keywordSymbiosis*-
dc.subject.keywordUracil/metabolism*-
dc.contributor.alternativeNameKim, Min Ji-
dc.contributor.alternativeNameRyu, Ji Hwan-
dc.contributor.affiliatedAuthorKim, Min Ji-
dc.contributor.affiliatedAuthorRyu, Ji Hwan-
dc.rights.accessRightsnot free-
dc.citation.volume153-
dc.citation.number4-
dc.citation.startPage797-
dc.citation.endPage811-
dc.identifier.bibliographicCitationCELL, Vol.153(4) : 797-811, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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