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Biochemical outcomes after robot-assisted radical prostatectomy in patients with follow-up more than 5-years

Authors
 Kwang Hyun Kim  ;  Sey Kiat Lim  ;  Tae-Young Shin  ;  Byung Ha Chung  ;  Sung Joon Hong  ;  Koon Ho Rha 
Citation
 ASIAN JOURNAL OF ANDROLOGY, Vol.15(3) : 404-408, 2013 
Journal Title
 ASIAN JOURNAL OF ANDROLOGY 
ISSN
 1008-682X 
Issue Date
2013
MeSH
Aged ; Disease-Free Survival ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Laparoscopy ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Grading ; Neoplasm Staging ; Neoplasm, Residual ; Proportional Hazards Models ; Prostate-Specific Antigen/blood* ; Prostatectomy* ; Prostatic Neoplasms/blood* ; Prostatic Neoplasms/pathology* ; Prostatic Neoplasms/surgery ; Robotics ; Survival Rate
Keywords
prostatectomy ; prostatic neoplasm ; recurrence ; robotics
Abstract
In this study, we assessed biochemical outcomes after robot-assisted radical prostatectomy (RARP). Between July 2005 and November 2007, one hundred and seventy-six consecutive patients treated by RARP without neoadjuvant treatment were included in this study. All procedures were performed by a single surgeon and the median follow-up period was 60 months (interquartile range (IQR): 59-69). The median prostate specific antigen was 7.50 ng ml(-1) (IQR: 5.14-11.45) and 39.2% of the patients were classified as intermediate risk and 15.3% were classified as high risk; on final pathological examination, 35.2% of the patients had non-organ confined disease and 37.5% and 14.2% had Gleason scores of 7 and 8-10, respectively. The biochemical recurrence (BCR)-free survival rates at 3 and 5 years were 85.6% and 81.2%, respectively. The 5-year BCR-free survival rates stratified by pathologic Gleason scores were 93.1% in Gleason scores of 6 or less, 74.5% in a Gleason score of 7, and 58.1% in Gleason scores of 8 or greater, respectively (P<0.001). When stratified by pathologic stage, the BCR-free survival rates were 89.8% in pT2 patients, 66.2% in pT3a patients, and 39.3% in pT3b patients at 5 years following RARP, respectively (P<0.001). Preoperative prostate-specific antigen (PSA), pathologic stage, postoperative Gleason score and surgical margin status were independently associated with BCR in multivariate analysis. In this study, we report biochemical outcomes after RARP with the longest follow-up periods to date in Asian men. We found that robotic surgery provided satisfactory biochemical outcomes, and that RARP is a safe and effective procedure in terms of oncologic outcomes.
Files in This Item:
T201303611.pdf Download
DOI
10.1038/aja.2013.5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Hyun(김광현)
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Shin, Tae Young(신태영)
Lim, Sey Kiat(임세이캣)
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88207
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