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Folfox4 as a Rescue Chemotherapy for Gemcitabine-Refractory Pancreatic Cancer

Authors
 Chung JW ; Jang HW ; Bang SM ; Song SY ; Chung JB ; Park SW ; Park JY ; Chung MJ 
Citation
 Hepato-Gastroenterology, Vol.60(122) : 363~367, 2013 
Journal Title
 Hepato-Gastroenterology 
ISSN
 0172-6390 
Issue Date
2013
Abstract
BACKGROUND/AIMS: This phase II study assessed the efficacy and safety of FOLFOX4 as a rescue therapy in patients with gemcitabine-refractory pancreatic cancer. METHODOLOGY: The study included patients with advanced pancreatic cancer who had failed gemcitabine-based chemotherapy. FOLFOX4 was administered biweekly as follows: oxaliplatin, 85 mg/m² as a 2-hour infusion (day 1); leucovorin, 200 mg/m²/day as a 2-hour infusion (days 1 and 2); 5-fluorouracil, bolus 400 mg/m²/day and 600 mg/m²/day as a 22-hour infusion (days 1 and 2). RESULTS: Forty-four patients received a total of 264 cycles of chemotherapy. There was 1 complete response (2.2%), 4 partial responses (9.1%), and 13 stable diseases (29.5%). The objective response rate was 11.4% and the tumor stabilization rate was 40.9%. The median time to progression was 9.9 weeks (95%CI: 8.2-11.5) and the median overall survival was 31.1 weeks (95%CI: 24.4-37.9). The common adverse events were hematologic toxicities: grade 3 or 4 neutropenia in 19 patients (43.2%), anemia in 9 patients (20.5%), and thrombocytopenia in 6 patients (13.5%). Grade 3 or 4 neuropathy occurred in 4 patients (9.1%). CONCLUSIONS: In gemcitabine-refractory pancreatic cancer, FOLFOX4 showed encouraging activity and was generally well-tolerated. However, careful attention needs to be paid to hematologic toxicities.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/87977
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
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