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Serum Adiponectin and Type 2 Diabetes: A 6-Year Follow-Up Cohort Study

Authors
 Sun Ha Jee  ;  Chul Woo Ahn  ;  Jong Suk Park  ;  Chang Gyu Park  ;  Hyon-Suk Kim  ;  Sang-Hak Lee  ;  Sungha Park  ;  Myoungsook Lee  ;  Chang Beom Lee  ;  Hye Soon Park  ;  Heejin Kimm  ;  Sung Hee Choi  ;  Jidong Sung  ;  Seungjoon Oh  ;  Hyojee Joung  ;  Sung Rae Kim  ;  Ho-Joong Youn  ;  Sun Mi Kim  ;  Hong Soo Lee  ;  Yejin Mok  ;  Eunmi Choi  ;  Young Duk Yun  ;  Soo-Jin Baek  ;  Jaeseong Jo  ;  Kap Bum Huh 
Citation
 DIABETES & METABOLISM JOURNAL, Vol.37(4) : 252-261, 2013 
Journal Title
 DIABETES & METABOLISM JOURNAL 
ISSN
 2233-6079 
Issue Date
2013
Keywords
Adiponectin ; Cohort studies ; Diabetes mellitus ; Impaired fasting glucose
Abstract
BACKGROUND: Studies on factors which may predict the risk of diabetes are scarce. This prospective cohort study was conducted to determine the association between adiponectin and type 2 diabetes among Korean men and women. METHODS: A total of 42,845 participants who visited one of seven health examination centers located in Seoul and Gyeonggi province, Republic of Korea between 2004 and 2008 were included in this study. The incidence rates of diabetes were determined through December 2011. To evaluate the effects of adiponectin on type 2 diabetes, the Cox proportional hazard model was used. RESULTS: Of the 40,005 participants, 959 developed type 2 diabetes during a 6-year follow-up. After the adjustment for age, body mass index (BMI), and waist circumference, the risks for type 2 diabetes in participants with normoglycemia had a 1.70-fold (95% confidence interval [CI], 1.21 to 2.38) increase in men and a 1.83-fold (95% CI, 1.17 to 2.86) increase in women with the lowest tertile of adiponectin when compared to the highest tertile of adiponectin. For participants with impaired fasting glucose (IFG), the risk for type 2 diabetes had a 1.46-fold (95% CI, 1.17 to 1.83) increase in men and a 2.52-fold (95% CI, 1.57 to 4.06) increase in women with the lowest tertile of adiponectin. Except for female participants with normoglycemia, all the risks remained significant after the adjustment for fasting glucose and other confounding variables. Surprisingly, BMI and waist circumference were not predictors of type 2 diabetes in men or women with IFG after adjustment for fasting glucose and other confounders. CONCLUSION: A strong association between adiponectin and diabetes was observed. The use of adiponectin as a predictor of type 2 diabetes is considered to be useful.
Files in This Item:
T201303285.pdf Download
DOI
10.4093/dmj.2013.37.4.252
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Kimm, Heejin(김희진) ORCID logo https://orcid.org/0000-0003-4526-0570
Mok, Ye Jin(목예진)
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87950
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