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Comparison of Prognostic Genomic Predictors in Colorectal Cancer

 Yun-Yong Park  ;  Sung Sook Lee  ;  Jae Yun Lim  ;  Sang Cheol Kim  ;  Sang Bae Kim  ;  Bo Hwa Sohn  ;  In-Sun Chu  ;  Sang Cheul Oh  ;  Eun Sung Park  ;  Woojin Jeong  ;  Sung Soo Kim  ;  Scott Kopetz  ;  Ju-Seog Lee 
 PLoS One, Vol.8(4) : e60778, 2013 
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 PLoS One 
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BACKGROUND: Although several prognostic genomic predictors have been identified from independent studies, it remains unclear whether these predictors are actually concordant with respect to their predictions for individual patients and which predictor performs best. We compared five prognostic genomic predictors, the V7RHS, the ColoGuideEx, the Meta163, the OncoDX, and the MDA114, in terms of predicting disease-free survival in two independent cohorts of patients with colorectal cancer. STUDY DESIGN: Using original classification algorithms, we tested the predictions of five genomic predictors for disease-free survival in two cohorts of patients with colorectal cancer (n = 229 and n = 168) and evaluated concordance of predictors in predicting outcomes for individual patients. RESULTS: We found that only two predictors, OncoDX and MDA114, demonstrated robust performance in identifying patients with poor prognosis in 2 independent cohorts. These two predictors also had modest but significant concordance of predicted outcome (r>0.3, P<0.001 in both cohorts). CONCLUSIONS: Further validation of developed genomic predictors is necessary. Despite the limited number of genes shared by OncoDX and MDA114, individual-patient outcomes predicted by these two predictors were significantly concordant.
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5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Eun Sung(박은성)
Lim, Jae Yun(임재윤)
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