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Pharmacogenomic Assessment of Outcomes of Pemetrexed-Treated Patients with Adenocarcinoma of the Lung

DC Field Value Language
dc.contributor.author강영애-
dc.contributor.author김대준-
dc.contributor.author김세규-
dc.contributor.author김주항-
dc.contributor.author라선영-
dc.contributor.author박형순-
dc.contributor.author이지현-
dc.contributor.author이철호-
dc.contributor.author장준-
dc.contributor.author정민규-
dc.contributor.author조병철-
dc.date.accessioned2014-12-18T09:17:27Z-
dc.date.available2014-12-18T09:17:27Z-
dc.date.issued2013-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87893-
dc.description.abstractPURPOSE: The main objective of this study was to evaluate the association between polymorphisms of the target genes of pemetrexed and clinical outcomes in non-small cell lung cancer (NSCLC) patients treated with pemetrexed. MATERIALS AND METHODS: We assessed polymorphisms at 8 sites in 4 genes [thymidylate synthase (TS), dihydrofolate reductase (DHFR; 1610, 680, 317, intron 1), methylenetetrahydrofolate reductase (MTHFR; 677, 1298), glycinamide ribonucleotide formyl transferase (GARFT; 2255)] associated with pemetrexed metabolism using polymerase chain reaction, gene scanning, and restriction fragment length polymorphism analysis in 90 patients with adenocarcinoma of the lung. RESULTS: Survival was significantly longer with pemetrexed in patients with TS 3RGCC/3RGCC or 3RGGC/3RGGC compared with the other groups (PFS; 5.2 months vs. 3.7 months, p=0.03: OS; 31.8 months vs. 18.5 months, p=0.001). Patients with DHFR 680CC experienced fatigue more frequently (50% vs. 8.6%, p=0.008). Polymorphisms of MTHFR and GARFT were not significantly associated with clinical outcomes of pemetrexed. CONCLUSION: The TS genotype was associated with survival and one DHFR polymorphism was associated with fatigue in NSCLC patients treated with pemetrexed. Further large prospective studies are required to identify other biomarkers that affect patients being treated with pemetrexed for adenocarcinoma of the lung.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/drug therapy*-
dc.subject.MESHAdenocarcinoma/genetics*-
dc.subject.MESHAdenocarcinoma/mortality-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAntimetabolites, Antineoplastic/pharmacology-
dc.subject.MESHAntimetabolites, Antineoplastic/therapeutic use*-
dc.subject.MESHAntimetabolites, Antineoplastic/toxicity-
dc.subject.MESHFemale-
dc.subject.MESHGlutamates/pharmacology-
dc.subject.MESHGlutamates/therapeutic use*-
dc.subject.MESHGlutamates/toxicity-
dc.subject.MESHGuanine/analogs & derivatives*-
dc.subject.MESHGuanine/pharmacology-
dc.subject.MESHGuanine/therapeutic use-
dc.subject.MESHGuanine/toxicity-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms/drug therapy*-
dc.subject.MESHLung Neoplasms/genetics*-
dc.subject.MESHLung Neoplasms/mortality-
dc.subject.MESHMale-
dc.subject.MESHMethylenetetrahydrofolate Reductase (NADPH2)/genetics-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPemetrexed-
dc.subject.MESHPharmacogenetics-
dc.subject.MESHPhosphoribosylglycinamide Formyltransferase/genetics-
dc.subject.MESHPolymorphism, Single Nucleotide*-
dc.subject.MESHTetrahydrofolate Dehydrogenase/genetics-
dc.subject.MESHThymidylate Synthase/genetics-
dc.titlePharmacogenomic Assessment of Outcomes of Pemetrexed-Treated Patients with Adenocarcinoma of the Lung-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMinkyu Jung-
dc.contributor.googleauthorChul Ho Lee-
dc.contributor.googleauthorHyung Soon Park-
dc.contributor.googleauthorJi Hyun Lee-
dc.contributor.googleauthorYoung Ae Kang-
dc.contributor.googleauthorSe Kyu Kim-
dc.contributor.googleauthorJoon Chang-
dc.contributor.googleauthorDae Joon Kim-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorJoo Hang Kim-
dc.contributor.googleauthorByoung Chul Cho-
dc.identifier.doi10.3349/ymj.2013.54.4.854-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00057-
dc.contributor.localIdA00368-
dc.contributor.localIdA00602-
dc.contributor.localIdA00945-
dc.contributor.localIdA03254-
dc.contributor.localIdA03472-
dc.contributor.localIdA03606-
dc.contributor.localIdA03822-
dc.contributor.localIdA01754-
dc.contributor.localIdA01316-
dc.contributor.localIdA03217-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid23709418-
dc.subject.keywordPolymorphism-
dc.subject.keywordlung neoplasms-
dc.subject.keywordpemetrexed-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNamePark, Hyung Soon-
dc.contributor.alternativeNameLee, Ji Hyun-
dc.contributor.alternativeNameLee, Chul Ho-
dc.contributor.alternativeNameChang, Joon-
dc.contributor.alternativeNameJung, Min Kyu-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.affiliatedAuthorKang, Young Ae-
dc.contributor.affiliatedAuthorKim, Dae Joon-
dc.contributor.affiliatedAuthorKim, Se Kyu-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorLee, Chul Ho-
dc.contributor.affiliatedAuthorChang, Joon-
dc.contributor.affiliatedAuthorJung, Min Kyu-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.contributor.affiliatedAuthorPark, Hyung Soon-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorLee, Ji Hyun-
dc.rights.accessRightsfree-
dc.citation.volume54-
dc.citation.number4-
dc.citation.startPage854-
dc.citation.endPage864-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.54(4) : 854-864, 2013-
dc.identifier.rimsid32596-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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