Serodiagnosis of Mycobacterium avium Complex and Mycobacterium abscessus Complex Pulmonary Disease by Use of IgA Antibodies to Glycopeptidolipid Core Antigen

Byeong-Ho Jeong; Su-Young Kim; Kyeongman Jeon; Soo-Youn Lee; Sung Jae Shin; Won-Jung Koh

doi:10.1128/JCM.00702-13

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Serodiagnosis of Mycobacterium avium Complex and Mycobacterium abscessus Complex Pulmonary Disease by Use of IgA Antibodies to Glycopeptidolipid Core Antigen

Authors: Byeong-Ho Jeong ; Su-Young Kim ; Kyeongman Jeon ; Soo-Youn Lee ; Sung Jae Shin ; Won-Jung Koh

Citation: JOURNAL OF CLINICAL MICROBIOLOGY, Vol.51(8) : 2747-2749, 2013

Journal Title: JOURNAL OF CLINICAL MICROBIOLOGY

ISSN: 0095-1137

Issue Date: 2013

MeSH: Aged ; Antibodies, Bacterial/blood* ; Antigens, Bacterial* ; Bacteriological Techniques/methods* ; Cohort Studies ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; Humans ; Immunoglobulin A/blood* ; Male ; Middle Aged ; Mycobacterium Infections, Nontuberculous/diagnosis* ; Pneumonia, Bacterial/diagnosis* ; Serologic Tests/methods

Keywords: Aged ; Antibodies, Bacterial/blood* ; Antigens, Bacterial* ; Bacteriological Techniques/methods* ; Cohort Studies ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; Humans ; Immunoglobulin A/blood* ; Male ; Middle Aged ; Mycobacterium Infections, Nontuberculous/diagnosis* ; Pneumonia, Bacterial/diagnosis* ; Serologic Tests/methods

Abstract: An enzyme immunoassay kit that detects serum IgA antibody reacting to glycopeptidolipid core antigen derived from Mycobacterium avium complex (MAC) was not useful for differentiating MAC pulmonary disease (PD) from Mycobacterium abscessus complex PD (MAB-PD). However, this assay could be useful for differentiating MAC- and MAB-PD from pulmonary tuberculosis. (This study has been registered at ClinicalTrials.gov under registration no. NCT00970801.).