First Case of Pulmonary Disease Caused by a Mycobacterium avium Complex Strain of Presumed Veterinary Origin in an Adult Human Patient

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MeSH: Aged ; Animals ; Antitubercular Agents/therapeutic use ; Bacterial Proteins ; Chaperonin 60 ; Cluster Analysis ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; DNA, Ribosomal/chemistry ; DNA, Ribosomal/genetics ; DNA-Directed RNA Polymerases ; Humans ; Male ; Molecular Sequence Data ; Mycobacterium avium Complex/classification ; Mycobacterium avium Complex/genetics ; Mycobacterium avium Complex/isolation & purification* ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Radiography, Thoracic ; Sequence Analysis, DNA ; Tomography, X-Ray Computed ; Treatment Failure ; Tuberculosis, Pulmonary/diagnosis* ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/microbiology* ; Zoonoses/microbiology* ; Zoonoses/transmission

Keywords: Aged ; Animals ; Antitubercular Agents/therapeutic use ; Bacterial Proteins ; Chaperonin 60 ; Cluster Analysis ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; DNA, Ribosomal/chemistry ; DNA, Ribosomal/genetics ; DNA-Directed RNA Polymerases ; Humans ; Male ; Molecular Sequence Data ; Mycobacterium avium Complex/classification ; Mycobacterium avium Complex/genetics ; Mycobacterium avium Complex/isolation & purification* ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Radiography, Thoracic ; Sequence Analysis, DNA ; Tomography, X-Ray Computed ; Treatment Failure ; Tuberculosis, Pulmonary/diagnosis* ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/microbiology* ; Zoonoses/microbiology* ; Zoonoses/transmission

Abstract: We report the first case of pulmonary disease caused by a strain of Mycobacterium avium complex of presumed veterinary origin in an elderly patient. All serial isolates were identified by multilocus sequence analysis based on rpoB, hsp65, and 16S rRNA fragments. Disease persisted despite macrolide-based combination antibiotic therapy.