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Changing treatment patterns in elderly patients with resectable colon cancer

Authors
 Gun Min Kim  ;  Joong Bae Ahn  ;  Sun Young Rha  ;  Han Sang Kim  ;  Beodeul Kang  ;  Min Whan Kim  ;  Soo Yeon Choi  ;  Jae Kyung Roh  ;  Hyun Cheol Chung  ;  Nam Kyu Kim  ;  Sang Joon Shin 
Citation
 ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, Vol.9(3) : 265-272, 2013 
Journal Title
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
ISSN
 1743-7555 
Issue Date
2013
MeSH
Age Factors ; Aged ; Aged, 80 and over ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/surgery ; Colonic Neoplasms/therapy* ; Comorbidity ; Female ; Humans ; Male ; Prognosis ; Survival Analysis ; Treatment Outcome
Keywords
colorectal cancer ; elderly ; prognosis ; resectable ; treatment pattern
Abstract
AIM:
To evaluate changing treatment patterns and survival outcomes of elderly patients (age 70 years or older) with resectable colon cancer over the past 15 years.
METHODS:
A total of 857 patients aged over 70 years who were managed for a resectable colon cancer between 1994 and 2010 were identified and their clinical variables were analyzed retrospectively.
RESULTS:
The patients' median age was 74 years (range: 70-94 years). In all, 171 patients (20%) were stage I, 375 (43.8%) were stage II and 311 (36.3%) were stage III. Over 95% of all patients underwent surgery regardless of age or diagnosis year. In stage III colon cancer the proportion of patients who received adjuvant treatment increased the more recent the year of diagnosis (1994-2000, 47%; 2001-2005, 66%; 2006-2010, 70%; P = 0.017). According to analysis by age group, older patients were less likely to receive adjuvant chemotherapy in both stage II (more than 75 years, 47.3%; 70-74 years, 59.4%; P < 0.001) and stage III (more than 75 years, 51.1%; 70-74 years, 76.7%; P < 0.001). Age-adjusted Charlson comorbidity index (CCI) is an independent prognostic factor for overall survival in stage II colon cancer patients.
CONCLUSION:
Elderly patients with resectable colon cancer received surgical treatment in more than 95% of cases without reference to age or diagnosis year. The proportion of patients who received adjuvant treatment increased according to the recency of diagnosis, but decreased abruptly according to increase in age.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/ajco.12042/abstract
DOI
10.1111/ajco.12042
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Beodeul(강버들) ORCID logo https://orcid.org/0000-0001-5177-8937
Kim, Gun Min(김건민) ORCID logo https://orcid.org/0000-0001-9167-8682
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Min Hwan(김민환) ORCID logo https://orcid.org/0000-0002-1595-6342
Kim, Han Sang(김한상) ORCID logo https://orcid.org/0000-0002-6504-9927
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87813
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