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Changing treatment patterns in elderly patients with resectable colon cancer

Authors
 Gun Min Kim  ;  Joong Bae Ahn  ;  Sun Young Rha  ;  Han Sang Kim  ;  Beodeul Kang  ;  Min Whan Kim  ;  Soo Yeon Choi  ;  Jae Kyung Roh  ;  Hyun Cheol Chung  ;  Nam Kyu Kim  ;  Sang Joon Shin 
Citation
 Asia-Pacific Journal of Clinical Oncology, Vol.9(3) : 265-272, 2013 
Journal Title
 Asia-Pacific Journal of Clinical Oncology 
ISSN
 1743-7555 
Issue Date
2013
Abstract
AIM: To evaluate changing treatment patterns and survival outcomes of elderly patients (age 70 years or older) with resectable colon cancer over the past 15 years. METHODS: A total of 857 patients aged over 70 years who were managed for a resectable colon cancer between 1994 and 2010 were identified and their clinical variables were analyzed retrospectively. RESULTS: The patients' median age was 74 years (range: 70-94 years). In all, 171 patients (20%) were stage I, 375 (43.8%) were stage II and 311 (36.3%) were stage III. Over 95% of all patients underwent surgery regardless of age or diagnosis year. In stage III colon cancer the proportion of patients who received adjuvant treatment increased the more recent the year of diagnosis (1994-2000, 47%; 2001-2005, 66%; 2006-2010, 70%; P = 0.017). According to analysis by age group, older patients were less likely to receive adjuvant chemotherapy in both stage II (more than 75 years, 47.3%; 70-74 years, 59.4%; P < 0.001) and stage III (more than 75 years, 51.1%; 70-74 years, 76.7%; P < 0.001). Age-adjusted Charlson comorbidity index (CCI) is an independent prognostic factor for overall survival in stage II colon cancer patients. CONCLUSION: Elderly patients with resectable colon cancer received surgical treatment in more than 95% of cases without reference to age or diagnosis year. The proportion of patients who received adjuvant treatment increased according to the recency of diagnosis, but decreased abruptly according to increase in age.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/ajco.12042/abstract
DOI
10.1111/ajco.12042
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강버들(Kang, Beodeul) ORCID logo https://orcid.org/0000-0001-5177-8937
김건민(Kim, Gun Min) ORCID logo https://orcid.org/0000-0001-9167-8682
김남규(Kim, Nam Kyu) ORCID logo https://orcid.org/0000-0003-0639-5632
김민환(Kim, Min Hwan) ORCID logo https://orcid.org/0000-0002-1595-6342
김한상(Kim, Han Sang) ORCID logo https://orcid.org/0000-0002-6504-9927
노재경(Roh, Jae Kyung)
라선영(Rha, Sun Young) ORCID logo https://orcid.org/0000-0002-2512-4531
신상준(Shin, Sang Joon) ORCID logo https://orcid.org/0000-0001-5350-7241
안중배(Ahn, Joong Bae) ORCID logo https://orcid.org/0000-0001-6787-1503
정현철(Chung, Hyun Cheol) ORCID logo https://orcid.org/0000-0002-0920-9471
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87813
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