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Midbrain-Driven Emotion and Reward Processing in Alcoholism

Authors
 E M Müller-Oehring  ;  Y-C Jung  ;  E V Sullivan  ;  W C Hawkes  ;  A Pfefferbaum  ;  T Schulte 
Citation
 NEUROPSYCHOPHARMACOLOGY, Vol.38(10) : 1844-1853, 2013 
Journal Title
 NEUROPSYCHOPHARMACOLOGY 
ISSN
 0893-133X 
Issue Date
2013
MeSH
Adult ; Aged ; Alcoholism/physiopathology* ; Alcoholism/psychology* ; Behavior, Addictive/physiopathology ; Brain Mapping ; Case-Control Studies ; Color Perception/physiology ; Emotions* ; Female ; Humans ; Male ; Mesencephalon/physiology* ; Middle Aged ; Neural Inhibition/physiology ; Photic Stimulation ; Reward* ; Stroop Test ; Visual Perception/physiology
Keywords
Adult ; Aged ; Alcoholism/physiopathology* ; Alcoholism/psychology* ; Behavior, Addictive/physiopathology ; Brain Mapping ; Case-Control Studies ; Color Perception/physiology ; Emotions* ; Female ; Humans ; Male ; Mesencephalon/physiology* ; Middle Aged ; Neural Inhibition/physiology ; Photic Stimulation ; Reward* ; Stroop Test ; Visual Perception/physiology
Abstract
Alcohol dependence is associated with impaired control over emotionally motivated actions, possibly associated with abnormalities in the frontoparietal executive control network and midbrain nodes of the reward network associated with automatic attention. To identify differences in the neural response to alcohol-related word stimuli, 26 chronic alcoholics (ALC) and 26 healthy controls (CTL) performed an alcohol-emotion Stroop Match-to-Sample task during functional MR imaging. Stroop contrasts were modeled for color-word incongruency (eg, word RED printed in green) and for alcohol (eg, BEER), positive (eg, HAPPY) and negative (eg, MAD) emotional word content relative to congruent word conditions (eg, word RED printed in red). During color-Stroop processing, ALC and CTL showed similar left dorsolateral prefrontal activation, and CTL, but not ALC, deactivated posterior cingulate cortex/cuneus. An interaction revealed a dissociation between alcohol-word and color-word Stroop processing: ALC activated midbrain and parahippocampal regions more than CTL when processing alcohol-word relative to color-word conditions. In ALC, the midbrain region was also invoked by negative emotional Stroop words thereby showing significant overlap of this midbrain activation for alcohol-related and negative emotional processing. Enhanced midbrain activation to alcohol-related words suggests neuroadaptation of dopaminergic midbrain systems. We speculate that such tuning is normally associated with behavioral conditioning to optimize responses but here contributed to automatic bias to alcohol-related stimuli.
Full Text
http://www.nature.com/npp/journal/v38/n10/full/npp2013102a.html
DOI
10.1038/npp.2013.102
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87679
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