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LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients.

Authors
 Sung Gwe Ahn  ;  Seung Myung Dong  ;  Akira Oshima  ;  Woo Ho Kim  ;  Hak Min Lee  ;  Seung Ah Lee  ;  Seung-hyun Kwon  ;  Ji-hae Lee  ;  Jae Myun Lee  ;  Joon Jeong  ;  Hy-De Lee  ;  Jeffrey E. Green 
Citation
 Breast Cancer Research and Treatment, Vol.141(1) : 89-99, 2013 
Journal Title
 Breast Cancer Research and Treatment 
ISSN
 0167-6806 
Issue Date
2013
Abstract
Lysyl oxidase-like 2 (LOXL2) is associated with invasiveness and metastasis in breast cancer. We analyzed the prognostic impact of LOXL2 for breast cancer patients and investigated the role of LOXL2 in breast cancer cell lines. Immunohistochemical study of LOXL2 expression was done in samples from 309 patients. Survival analysis was performed using log-rank test and Cox regression hazard model. After identification of LOXL2 expression in breast cancer cell lines, we performed matrigel invasion and wound-healing assays with LOXL2-silenced cell lines. In the human study, LOXL2 was expressed in 16.2 % of patients. Comparing the LOXL2-positive versus negative groups, there was a significantly higher proportion of estrogen receptor-negative patients (54.0 vs. 37.0 %, respectively; p = 0.029) and triple-negative patients (34.0 vs. 18.0 %; p = 0.022) in the positive group. In multivariate analysis for overall survival and metastasis-free survival, positive LOXL2 was demonstrated as a poor prognostic factor (HR 2.27 and 2.10, respectively). In vitro study indicated that LOXL2 silencing induces a mesenchymal–epithelial transition-like process in basal cell lines (MDA-MB-231 and BT549) associated with decreased invasive and migratory properties. These clinical and preclinical data confirm that higher LOXL2 expression is associated with invasiveness of basal-like breast cancer cells and lower survival of breast cancer patients. Our results suggest the clinical value of LOXL2 as a therapeutic target in breast cancer.
Full Text
http://link.springer.com/article/10.1007%2Fs10549-013-2662-3
DOI
10.1007/s10549-013-2662-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
안성귀(Ahn, Sung Gwe) ORCID logo https://orcid.org/0000-0002-8778-9686
이재면(Lee, Jae Myun) ORCID logo https://orcid.org/0000-0002-5273-3113
이학민(Lee, Hak Min)
이희대(Lee, Hy De)
정준(Jeong, Joon) ORCID logo https://orcid.org/0000-0003-0397-0005
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87669
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