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LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients.

 Sung Gwe Ahn  ;  Seung Myung Dong  ;  Akira Oshima  ;  Woo Ho Kim  ;  Hak Min Lee  ;  Seung Ah Lee  ;  Seung-hyun Kwon  ;  Ji-hae Lee  ;  Jae Myun Lee  ;  Joon Jeong  ;  Hy-De Lee  ;  Jeffrey E. Green 
 Breast Cancer Research and Treatment, Vol.141(1) : 89-99, 2013 
Journal Title
 Breast Cancer Research and Treatment 
Issue Date
Adult ; Amino Acid Oxidoreductases/analysis* ; Amino Acid Oxidoreductases/biosynthesis ; Amino Acid Oxidoreductases/genetics ; Breast Neoplasms/chemistry* ; Breast Neoplasms/genetics ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Carcinoma/chemistry* ; Carcinoma/genetics ; Carcinoma/mortality ; Carcinoma/pathology ; Carcinoma in Situ/chemistry ; Carcinoma in Situ/genetics ; Carcinoma in Situ/mortality ; Carcinoma in Situ/pathology ; Cell Line, Tumor ; Cell Movement ; Collagen ; Disease-Free Survival ; Drug Combinations ; Epithelial-Mesenchymal Transition ; Female ; Gene Expression Regulation, Neoplastic* ; Humans ; In Situ Hybridization ; Kaplan-Meier Estimate ; Laminin ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasm Proteins/analysis* ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/genetics ; Neoplasms, Multiple Primary/chemistry ; Neoplasms, Multiple Primary/genetics ; Neoplasms, Multiple Primary/mortality ; Neoplasms, Multiple Primary/pathology ; Phyllodes Tumor/chemistry ; Phyllodes Tumor/genetics ; Phyllodes Tumor/mortality ; Phyllodes Tumor/pathology ; Prognosis ; Proportional Hazards Models ; Proteoglycans ; RNA Interference ; RNA, Small Interfering/pharmacology ; Survival Analysis ; Tissue Array Analysis ; Triple Negative Breast Neoplasms/chemistry ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/mortality ; Triple Negative Breast Neoplasms/pathology
Breast cancer ; LOXL2 ; Invasiveness ; Triple negative
Lysyl oxidase-like 2 (LOXL2) is associated with invasiveness and metastasis in breast cancer. We analyzed the prognostic impact of LOXL2 for breast cancer patients and investigated the role of LOXL2 in breast cancer cell lines. Immunohistochemical study of LOXL2 expression was done in samples from 309 patients. Survival analysis was performed using log-rank test and Cox regression hazard model. After identification of LOXL2 expression in breast cancer cell lines, we performed matrigel invasion and wound-healing assays with LOXL2-silenced cell lines. In the human study, LOXL2 was expressed in 16.2 % of patients. Comparing the LOXL2-positive versus negative groups, there was a significantly higher proportion of estrogen receptor-negative patients (54.0 vs. 37.0 %, respectively; p = 0.029) and triple-negative patients (34.0 vs. 18.0 %; p = 0.022) in the positive group. In multivariate analysis for overall survival and metastasis-free survival, positive LOXL2 was demonstrated as a poor prognostic factor (HR 2.27 and 2.10, respectively). In vitro study indicated that LOXL2 silencing induces a mesenchymal–epithelial transition-like process in basal cell lines (MDA-MB-231 and BT549) associated with decreased invasive and migratory properties. These clinical and preclinical data confirm that higher LOXL2 expression is associated with invasiveness of basal-like breast cancer cells and lower survival of breast cancer patients. Our results suggest the clinical value of LOXL2 as a therapeutic target in breast cancer.
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1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Lee, Jae Myun(이재면) ORCID logo https://orcid.org/0000-0002-5273-3113
Lee, Hak Min(이학민)
Lee, Hy De(이희대)
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
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