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Prognostic Factors for Patients with Bone-Only Metastasis in Breast Cancer

Authors
 Sung Gwe Ahn  ;  Hak Min Lee  ;  Sang-Hoon Cho  ;  Seung Ah Lee  ;  Seung Hyun Hwang  ;  Joon Jeong  ;  Hy-De Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.54(5) : 1168-1177, 2013 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2013
MeSH
Adult ; Antineoplastic Agents/therapeutic use ; Bone Neoplasms/drug therapy ; Bone Neoplasms/genetics ; Bone Neoplasms/secondary* ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology* ; Female ; Humans ; Middle Aged ; Multivariate Analysis ; Prognosis ; Receptors, Estrogen/genetics ; Receptors, Progesterone/genetics ; Regression Analysis ; Retrospective Studies ; Survival Analysis
Keywords
Breast neoplasm ; bone metastses ; bisphosphonate
Abstract
PURPOSE: Bone is the most frequent site of metastasis among breast cancer patients. We investigated prognostic factors affecting survival following bone-only metastasis in breast cancer patients. MATERIALS AND METHODS: The medical records of breast cancer patients who were treated and followed at Gangnam Severance Hospital retrospectively reviewed to identify patients with bone-only metastasis. RESULTS: The median time from the diagnosis of bone-only metastasis to the last follow-up or death was 55.2 [95% confidence interval (CI), 38.6-71.9] months. The Kaplan-Meier overall survival estimate at 10 years for all patients was 34.9%. In the multivariate Cox regression model, bisphosphonate treatment [hazard ratio=0.18; 95% CI, 0.07-0.43], estrogen receptor positivity (hazard ratio=0.51; 95% CI, 0.28-0.94), and solitary bone metastasis (hazard ratio=0.32; 95% CI, 0.14-0.72) were significantly associated with longer overall survival in the bone-only recurrence group. Among the treatment modalities, only bisphosphonate treatment was identified as a significant prognostic factor. CONCLUSION: Identifying the factors influencing breast cancer mortality after bone-only metastasis will help clarify the clinical course and improve the treatment outcome for patients with breast cancer and bone-only metastasis. Bisphosphonates, as a significant prognostic factor, warrant further investigation.
Files in This Item:
T201302885.pdf Download
DOI
10.3349/ymj.2013.54.5.1168
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Lee, Seung Ah(이승아)
Lee, Hak Min(이학민)
Lee, Hy De(이희대)
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
Hwang, Seung Hyun(황승현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87668
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