Cited 91 times in
Prognostic Factors for Patients with Bone-Only Metastasis in Breast Cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안성귀 | - |
dc.contributor.author | 이승아 | - |
dc.contributor.author | 이학민 | - |
dc.contributor.author | 이희대 | - |
dc.contributor.author | 정준 | - |
dc.contributor.author | 황승현 | - |
dc.date.accessioned | 2014-12-18T09:10:21Z | - |
dc.date.available | 2014-12-18T09:10:21Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87668 | - |
dc.description.abstract | PURPOSE: Bone is the most frequent site of metastasis among breast cancer patients. We investigated prognostic factors affecting survival following bone-only metastasis in breast cancer patients. MATERIALS AND METHODS: The medical records of breast cancer patients who were treated and followed at Gangnam Severance Hospital retrospectively reviewed to identify patients with bone-only metastasis. RESULTS: The median time from the diagnosis of bone-only metastasis to the last follow-up or death was 55.2 [95% confidence interval (CI), 38.6-71.9] months. The Kaplan-Meier overall survival estimate at 10 years for all patients was 34.9%. In the multivariate Cox regression model, bisphosphonate treatment [hazard ratio=0.18; 95% CI, 0.07-0.43], estrogen receptor positivity (hazard ratio=0.51; 95% CI, 0.28-0.94), and solitary bone metastasis (hazard ratio=0.32; 95% CI, 0.14-0.72) were significantly associated with longer overall survival in the bone-only recurrence group. Among the treatment modalities, only bisphosphonate treatment was identified as a significant prognostic factor. CONCLUSION: Identifying the factors influencing breast cancer mortality after bone-only metastasis will help clarify the clinical course and improve the treatment outcome for patients with breast cancer and bone-only metastasis. Bisphosphonates, as a significant prognostic factor, warrant further investigation. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antineoplastic Agents/therapeutic use | - |
dc.subject.MESH | Bone Neoplasms/drug therapy | - |
dc.subject.MESH | Bone Neoplasms/genetics | - |
dc.subject.MESH | Bone Neoplasms/secondary* | - |
dc.subject.MESH | Breast Neoplasms/drug therapy | - |
dc.subject.MESH | Breast Neoplasms/genetics | - |
dc.subject.MESH | Breast Neoplasms/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Receptors, Estrogen/genetics | - |
dc.subject.MESH | Receptors, Progesterone/genetics | - |
dc.subject.MESH | Regression Analysis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | Prognostic Factors for Patients with Bone-Only Metastasis in Breast Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Sung Gwe Ahn | - |
dc.contributor.googleauthor | Hak Min Lee | - |
dc.contributor.googleauthor | Sang-Hoon Cho | - |
dc.contributor.googleauthor | Seung Ah Lee | - |
dc.contributor.googleauthor | Seung Hyun Hwang | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.contributor.googleauthor | Hy-De Lee | - |
dc.identifier.doi | 10.3349/ymj.2013.54.5.1168 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02231 | - |
dc.contributor.localId | A02918 | - |
dc.contributor.localId | A03272 | - |
dc.contributor.localId | A03347 | - |
dc.contributor.localId | A03727 | - |
dc.contributor.localId | A04470 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 23918566 | - |
dc.subject.keyword | Breast neoplasm | - |
dc.subject.keyword | bone metastses | - |
dc.subject.keyword | bisphosphonate | - |
dc.contributor.alternativeName | Ahn, Sung Gwe | - |
dc.contributor.alternativeName | Lee, Seung Ah | - |
dc.contributor.alternativeName | Lee, Hak Min | - |
dc.contributor.alternativeName | Lee, Hy De | - |
dc.contributor.alternativeName | Jeong, Joon | - |
dc.contributor.alternativeName | Hwang, Seung Hyun | - |
dc.contributor.affiliatedAuthor | Ahn, Sung Gwe | - |
dc.contributor.affiliatedAuthor | Lee, Seung Ah | - |
dc.contributor.affiliatedAuthor | Lee, Hak Min | - |
dc.contributor.affiliatedAuthor | Lee, Hy De | - |
dc.contributor.affiliatedAuthor | Jeong, Joon | - |
dc.contributor.affiliatedAuthor | Hwang, Seung Hyun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 54 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1168 | - |
dc.citation.endPage | 1177 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.54(5) : 1168-1177, 2013 | - |
dc.identifier.rimsid | 32196 | - |
dc.type.rims | ART | - |
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