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Epigenetic modification after inhibition of IGF-1R signaling in human central nervous system atypical teratoid rhabdoid tumor (AT/RT)

Authors
 Kyu-Won Shim  ;  Guifa Xi  ;  Barbara-Mania Farnell  ;  Dong-Seok Kim  ;  Takao Tsurubuchi  ;  Tadanori Tomita  ;  C. Shekhar Mayanil 
Citation
 CHILDS NERVOUS SYSTEM, Vol.29(8) : 1245-1251, 2013 
Journal Title
 CHILDS NERVOUS SYSTEM 
ISSN
 0256-7040 
Issue Date
2013
Keywords
Epigenetic modification ; Atypical teratoid rhabdoid tumor ; Histone deacetylase ; Histone acetyl transferase ; IGF-1R ; Picropodophyllin
Abstract
OBJECTIVE: This study investigated epigenetic modifications in human central nervous system atypical teratoid rhabdoid tumors (AT/RTs), in response to inhibition of insulin-like growth factor receptor 1 (IGF-1R). MATERIALS AND METHODS: Tumor tissue was obtained from two pediatric patients, tissue was dissociated, and primary cultures were established. Cultured cells were treated with picropodophyllin (PPP; 0, 1, and 2 μM for 48 h), a selective IGF-1R inhibitor. Histone acetylation and methylation patterns (H3K9ac, H3K18ac, H3K4me3, H3K27me3) and levels of histone deacetylases (HDACs; HDAC1, HDAC3, and SirT1) and histone acetyl transferases (GCN5 and p300) were examined. H3K9ac and H3K18ac decreased in response to treatment with PPP. HDAC levels showed a biphasic response, increasing with 1 μM PPP, but then decreasing with 2 μM PPP. CONCLUSION: Inhibition of IGF-1R modified epigenetic status in AT/RT. Determining the mechanisms behind these modifications will guide the development of novel therapeutic targets for this malignant embryonal cancer.
Full Text
http://link.springer.com/article/10.1007%2Fs00381-013-2087-7
DOI
10.1007/s00381-013-2087-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
Shim, Kyu Won(심규원) ORCID logo https://orcid.org/0000-0002-9441-7354
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87582
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