Cited 6 times in
Epigenetic modification after inhibition of IGF-1R signaling in human central nervous system atypical teratoid rhabdoid tumor (AT/RT)
DC Field | Value | Language |
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dc.contributor.author | 김동석 | - |
dc.contributor.author | 심규원 | - |
dc.date.accessioned | 2014-12-18T09:07:33Z | - |
dc.date.available | 2014-12-18T09:07:33Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0256-7040 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87582 | - |
dc.description.abstract | OBJECTIVE: This study investigated epigenetic modifications in human central nervous system atypical teratoid rhabdoid tumors (AT/RTs), in response to inhibition of insulin-like growth factor receptor 1 (IGF-1R). MATERIALS AND METHODS: Tumor tissue was obtained from two pediatric patients, tissue was dissociated, and primary cultures were established. Cultured cells were treated with picropodophyllin (PPP; 0, 1, and 2 μM for 48 h), a selective IGF-1R inhibitor. Histone acetylation and methylation patterns (H3K9ac, H3K18ac, H3K4me3, H3K27me3) and levels of histone deacetylases (HDACs; HDAC1, HDAC3, and SirT1) and histone acetyl transferases (GCN5 and p300) were examined. H3K9ac and H3K18ac decreased in response to treatment with PPP. HDAC levels showed a biphasic response, increasing with 1 μM PPP, but then decreasing with 2 μM PPP. CONCLUSION: Inhibition of IGF-1R modified epigenetic status in AT/RT. Determining the mechanisms behind these modifications will guide the development of novel therapeutic targets for this malignant embryonal cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CHILDS NERVOUS SYSTEM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Epigenetic modification after inhibition of IGF-1R signaling in human central nervous system atypical teratoid rhabdoid tumor (AT/RT) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Kyu-Won Shim | - |
dc.contributor.googleauthor | Guifa Xi | - |
dc.contributor.googleauthor | Barbara-Mania Farnell | - |
dc.contributor.googleauthor | Dong-Seok Kim | - |
dc.contributor.googleauthor | Takao Tsurubuchi | - |
dc.contributor.googleauthor | Tadanori Tomita | - |
dc.contributor.googleauthor | C. Shekhar Mayanil | - |
dc.identifier.doi | 10.1007/s00381-013-2087-7 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00402 | - |
dc.contributor.localId | A02187 | - |
dc.relation.journalcode | J00525 | - |
dc.identifier.eissn | 1433-0350 | - |
dc.identifier.pmid | Epigenetic modification ; Atypical teratoid rhabdoid tumor ; Histone deacetylase ; Histone acetyl transferase ; IGF-1R ; Picropodophyllin | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00381-013-2087-7 | - |
dc.subject.keyword | Epigenetic modification | - |
dc.subject.keyword | Atypical teratoid rhabdoid tumor | - |
dc.subject.keyword | Histone deacetylase | - |
dc.subject.keyword | Histone acetyl transferase | - |
dc.subject.keyword | IGF-1R | - |
dc.subject.keyword | Picropodophyllin | - |
dc.contributor.alternativeName | Kim, Dong Seok | - |
dc.contributor.alternativeName | Shim, Kyu Won | - |
dc.contributor.affiliatedAuthor | Kim, Dong Seok | - |
dc.contributor.affiliatedAuthor | Shim, Kyu Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1245 | - |
dc.citation.endPage | 1251 | - |
dc.identifier.bibliographicCitation | CHILDS NERVOUS SYSTEM, Vol.29(8) : 1245-1251, 2013 | - |
dc.identifier.rimsid | 34328 | - |
dc.type.rims | ART | - |
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