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Epigenetic modification after inhibition of IGF-1R signaling in human central nervous system atypical teratoid rhabdoid tumor (AT/RT)

DC Field Value Language
dc.contributor.author김동석-
dc.contributor.author심규원-
dc.date.accessioned2014-12-18T09:07:33Z-
dc.date.available2014-12-18T09:07:33Z-
dc.date.issued2013-
dc.identifier.issn0256-7040-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87582-
dc.description.abstractOBJECTIVE: This study investigated epigenetic modifications in human central nervous system atypical teratoid rhabdoid tumors (AT/RTs), in response to inhibition of insulin-like growth factor receptor 1 (IGF-1R). MATERIALS AND METHODS: Tumor tissue was obtained from two pediatric patients, tissue was dissociated, and primary cultures were established. Cultured cells were treated with picropodophyllin (PPP; 0, 1, and 2 μM for 48 h), a selective IGF-1R inhibitor. Histone acetylation and methylation patterns (H3K9ac, H3K18ac, H3K4me3, H3K27me3) and levels of histone deacetylases (HDACs; HDAC1, HDAC3, and SirT1) and histone acetyl transferases (GCN5 and p300) were examined. H3K9ac and H3K18ac decreased in response to treatment with PPP. HDAC levels showed a biphasic response, increasing with 1 μM PPP, but then decreasing with 2 μM PPP. CONCLUSION: Inhibition of IGF-1R modified epigenetic status in AT/RT. Determining the mechanisms behind these modifications will guide the development of novel therapeutic targets for this malignant embryonal cancer.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCHILDS NERVOUS SYSTEM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEpigenetic modification after inhibition of IGF-1R signaling in human central nervous system atypical teratoid rhabdoid tumor (AT/RT)-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorKyu-Won Shim-
dc.contributor.googleauthorGuifa Xi-
dc.contributor.googleauthorBarbara-Mania Farnell-
dc.contributor.googleauthorDong-Seok Kim-
dc.contributor.googleauthorTakao Tsurubuchi-
dc.contributor.googleauthorTadanori Tomita-
dc.contributor.googleauthorC. Shekhar Mayanil-
dc.identifier.doi10.1007/s00381-013-2087-7-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00402-
dc.contributor.localIdA02187-
dc.relation.journalcodeJ00525-
dc.identifier.eissn1433-0350-
dc.identifier.pmidEpigenetic modification ; Atypical teratoid rhabdoid tumor ; Histone deacetylase ; Histone acetyl transferase ; IGF-1R ; Picropodophyllin-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00381-013-2087-7-
dc.subject.keywordEpigenetic modification-
dc.subject.keywordAtypical teratoid rhabdoid tumor-
dc.subject.keywordHistone deacetylase-
dc.subject.keywordHistone acetyl transferase-
dc.subject.keywordIGF-1R-
dc.subject.keywordPicropodophyllin-
dc.contributor.alternativeNameKim, Dong Seok-
dc.contributor.alternativeNameShim, Kyu Won-
dc.contributor.affiliatedAuthorKim, Dong Seok-
dc.contributor.affiliatedAuthorShim, Kyu Won-
dc.rights.accessRightsnot free-
dc.citation.volume29-
dc.citation.number8-
dc.citation.startPage1245-
dc.citation.endPage1251-
dc.identifier.bibliographicCitationCHILDS NERVOUS SYSTEM, Vol.29(8) : 1245-1251, 2013-
dc.identifier.rimsid34328-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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