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Apparent Diffusion Coefficient of Uterine Leiomyoma as a Predictor of the Potential Response to Uterine Artery Embolization

DC Field Value Language
dc.contributor.author김만득-
dc.contributor.author박성일-
dc.contributor.author원종윤-
dc.contributor.author이광훈-
dc.contributor.author이도연-
dc.contributor.author이명수-
dc.contributor.author정대철-
dc.date.accessioned2014-12-18T09:07:04Z-
dc.date.available2014-12-18T09:07:04Z-
dc.date.issued2013-
dc.identifier.issn1051-0443-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87567-
dc.description.abstractPURPOSE: To determine the utility of the apparent diffusion coefficient (ADC) of uterine leiomyoma for prediction of the potential response to uterine artery embolization (UAE). MATERIALS AND METHODS: This prospective study included 49 patients with uterine leiomyomas who underwent diffusion-weighted magnetic resonance (MR) imaging before UAE between May 2011 and January 2012. All patients also underwent 3-month follow-up MR imaging after UAE. Using conventional and diffusion-weighted MR imaging sequences, 72 uterine leiomyomas ≥ 3 cm were prospectively evaluated. The volume of each leiomyoma was calculated, and quantitative measurement of ADC was performed. Regression analysis was used to evaluate the relationship between ADC and volumetric response after UAE. Receiver operating characteristic curve analysis was performed to determine the sensitivity and specificity of ADC for prediction of the potential response to UAE. Interclass correlation coefficient analysis was used to assess interobserver variability between two radiologists. RESULTS: Volume reduction rates of leiomyomas after UAE ranged from 0.2%-89.1% (mean, 44.1%). ADC ranged from 0.559 × 10(-3) mm(2)/s to 1.814 × 10(-3) mm(2)/s (mean, 1.170 × 10(-3) mm(2)/s). ADC was statistically significantly related to volumetric response of leiomyomas (P = .014). Using a threshold of 1.092 × 10(-3) mm(2)/s, the sensitivity and specificity of ADC for prediction of > 50% volume reduction of the leiomyoma after UAE were 82.6% and 52.3%, respectively. Using a threshold of 1.023 × 10(-3) mm(2)/s, the sensitivity and specificity of ADC for prediction of < 30% volume reduction were 80.8% and 33.3%, respectively. The interclass correlation coefficient for measuring ADC of uterine leiomyomas between two radiologists was 0.98. CONCLUSIONS: ADC of uterine leiomyomas was significantly related to the volume reduction after UAE. ADC may be useful in predicting the potential response to UAE. A high ADC of the uterine leiomyoma may be associated with a greater volume reduction after UAE.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHDiffusion Magnetic Resonance Imaging/methods*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImage Interpretation, Computer-Assisted/methods*-
dc.subject.MESHImaging, Three-Dimensional/methods*-
dc.subject.MESHLeiomyoma/pathology*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHObserver Variation-
dc.subject.MESHPrognosis-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHTumor Burden-
dc.subject.MESHUterine Artery Embolization/methods*-
dc.subject.MESHUterine Neoplasms/pathology*-
dc.subject.MESHUterine Neoplasms/therapy*-
dc.titleApparent Diffusion Coefficient of Uterine Leiomyoma as a Predictor of the Potential Response to Uterine Artery Embolization-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorMu Sook Lee-
dc.contributor.googleauthorMan Deuk Kim-
dc.contributor.googleauthorDae Chul Jung-
dc.contributor.googleauthorMyungsu Lee-
dc.contributor.googleauthorJong Yun Won-
dc.contributor.googleauthorSung Il Park-
dc.contributor.googleauthorDo Yun Lee-
dc.contributor.googleauthorKwang-hun Lee-
dc.identifier.doi10.1016/j.jvir.2013.05.054-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00420-
dc.contributor.localIdA01510-
dc.contributor.localIdA02718-
dc.contributor.localIdA02751-
dc.contributor.localIdA03592-
dc.contributor.localIdA02443-
dc.contributor.localIdA02674-
dc.relation.journalcodeJ01922-
dc.identifier.eissn1535-7732-
dc.identifier.pmid23673572-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1051044313010543-
dc.subject.keywordADC-
dc.subject.keywordDW-
dc.subject.keywordROC-
dc.subject.keywordUAE-
dc.subject.keywordVRR-
dc.subject.keywordapparent diffusion coefficient-
dc.subject.keyworddiffusion-weighted-
dc.subject.keywordreceiver operating characteristic-
dc.subject.keyworduterine artery embolization-
dc.subject.keywordvolume reduction rate-
dc.contributor.alternativeNameKim, Man Deuk-
dc.contributor.alternativeNamePark, Sung Il-
dc.contributor.alternativeNameWon, Jong Yun-
dc.contributor.alternativeNameLee, Kwang Hoon-
dc.contributor.alternativeNameLee, Do Yun-
dc.contributor.alternativeNameLee, Myung Su-
dc.contributor.alternativeNameJung, Dae Chul-
dc.contributor.affiliatedAuthorKim, Man Deuk-
dc.contributor.affiliatedAuthorPark, Sung Il-
dc.contributor.affiliatedAuthorLee, Do Yun-
dc.contributor.affiliatedAuthorLee, Myung Su-
dc.contributor.affiliatedAuthorJung, Dae Chul-
dc.contributor.affiliatedAuthorWon, Jong Yun-
dc.contributor.affiliatedAuthorLee, Kwang Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume24-
dc.citation.number9-
dc.citation.startPage1361-
dc.citation.endPage1365-
dc.identifier.bibliographicCitationJOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, Vol.24(9) : 1361-1365, 2013-
dc.identifier.rimsid34316-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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