Cited 24 times in
Soluble Receptor for Advanced Glycation End Products Alleviates Nephritis in (NZB/NZW)F1 Mice
DC Field | Value | Language |
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dc.contributor.author | 김지혜 | - |
dc.contributor.author | 박규형 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 박용범 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 이수곤 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 홍성유 | - |
dc.date.accessioned | 2014-12-18T09:06:20Z | - |
dc.date.available | 2014-12-18T09:06:20Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0004-3591 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87543 | - |
dc.description.abstract | OBJECTIVE: To investigate the efficacy of different doses of the soluble form of the receptor for advanced glycation end products (sRAGE) (conjugated to the Fc portion of immunoglobulin) in the treatment of nephritis in lupus-prone mice, in comparison with the efficacy of combination therapy with mycophenolate mofetil plus prednisolone. METHODS: Twenty-eight female (NZB/NZW)F1 mice were divided into 5 groups (untreated, sRAGE [dose groups of 0.5, 1, or 2 μg], or mycophenolate mofetil plus prednisolone). Proteinuria and histologic damage were evaluated. Immune complex deposition and the nuclear translocation of NF-κB in the kidney tissue were assessed by immunofluorescence staining. Serum concentrations of anti-double-stranded DNA (anti-dsDNA) and IgG subclasses were also measured. The population of T cells was evaluated using a fluorescence-activated cell sorter, and expression of intracellular adhesion molecule 1 and vascular cell adhesion molecule 1 in the kidney tissue was assessed by immunohistochemical staining. RESULTS: In comparison with untreated mice, mice treated with 1 or 2 μg sRAGE showed significantly reduced proteinuria and attenuated histologic renal damage, with efficacy comparable to that of combination therapy. Treatment with 2 μg sRAGE significantly reduced immune complex deposition and decreased the serum concentrations of anti-dsDNA, IgG2a, IgG2b, and IgG3. In addition, sRAGE interrupted the nuclear translocation of NF-κB in the kidney, resulting in reduction in the expression of downstream genes of NF-κB in vivo and in vitro. Furthermore, sRAGE effectively modified T cell populations. CONCLUSION: Treatment with sRAGE significantly improved nephritis in lupus-prone mice, with efficacy comparable to that of standard induction treatment for lupus nephritis. These data suggest that sRAGE has antiinflammatory effects on the pathophysiology of lupus nephritis and could serve as a potent new therapy for this disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | Arthritis & Rheumatism | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Inflammatory Agents/therapeutic use* | - |
dc.subject.MESH | Antigen-Antibody Complex/metabolism | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Kidney/metabolism | - |
dc.subject.MESH | Kidney/pathology | - |
dc.subject.MESH | Lupus Nephritis/pathology | - |
dc.subject.MESH | Lupus Nephritis/therapy* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred NZB | - |
dc.subject.MESH | Mycophenolic Acid/analogs & derivatives | - |
dc.subject.MESH | Mycophenolic Acid/therapeutic use | - |
dc.subject.MESH | NF-kappa B | - |
dc.subject.MESH | Prednisolone/therapeutic use | - |
dc.subject.MESH | Proteinuria | - |
dc.subject.MESH | Receptor for Advanced Glycation End Products | - |
dc.subject.MESH | Receptors, Immunologic/therapeutic use* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Soluble Receptor for Advanced Glycation End Products Alleviates Nephritis in (NZB/NZW)F1 Mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.contributor.googleauthor | Kyu-Hyung Park | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Ji-Hye Kim | - |
dc.contributor.googleauthor | Sung-Yu Hong | - |
dc.contributor.googleauthor | Soo-Kon Lee | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.identifier.doi | 10.1002/art.37955 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01441 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02889 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04400 | - |
dc.contributor.localId | A01001 | - |
dc.contributor.localId | A02824 | - |
dc.relation.journalcode | J00239 | - |
dc.identifier.pmid | 23553192 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/art.37955/abstract | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Anti-Inflammatory Agents/therapeutic use* | - |
dc.subject.keyword | Antigen-Antibody Complex/metabolism | - |
dc.subject.keyword | Disease Models, Animal | - |
dc.subject.keyword | Drug Therapy, Combination | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Kidney/metabolism | - |
dc.subject.keyword | Kidney/pathology | - |
dc.subject.keyword | Lupus Nephritis/pathology | - |
dc.subject.keyword | Lupus Nephritis/therapy* | - |
dc.subject.keyword | Mice | - |
dc.subject.keyword | Mice, Inbred NZB | - |
dc.subject.keyword | Mycophenolic Acid/analogs & derivatives | - |
dc.subject.keyword | Mycophenolic Acid/therapeutic use | - |
dc.subject.keyword | NF-kappa B | - |
dc.subject.keyword | Prednisolone/therapeutic use | - |
dc.subject.keyword | Proteinuria | - |
dc.subject.keyword | Receptor for Advanced Glycation End Products | - |
dc.subject.keyword | Receptors, Immunologic/therapeutic use* | - |
dc.subject.keyword | Treatment Outcome | - |
dc.contributor.alternativeName | Kim, Ji Hye | - |
dc.contributor.alternativeName | Park, Kyu Hyung | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Lee, Sang Won | - |
dc.contributor.alternativeName | Lee, Soo Kon | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Hong, Sung Yu | - |
dc.contributor.affiliatedAuthor | Park, Kyu Hyung | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Lee, Soo Kon | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Sung Yu | - |
dc.contributor.affiliatedAuthor | Kim, Ji Hye | - |
dc.contributor.affiliatedAuthor | Lee, Sang Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 65 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1902 | - |
dc.citation.endPage | 1912 | - |
dc.identifier.bibliographicCitation | Arthritis & Rheumatism, Vol.65(7) : 1902-1912, 2013 | - |
dc.identifier.rimsid | 34297 | - |
dc.type.rims | ART | - |
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