4 509

Cited 12 times in

Increased GABA-A Receptor Binding and Reduced Connectivity at the Motor Cortex in Children with Hemiplegic Cerebral Palsy: A Multimodal Investigation Using 18F-Fluoroflumazenil PET, Immunohistochemistry, and MR Imaging

DC Field Value Language
dc.contributor.author박범희-
dc.contributor.author박은숙-
dc.contributor.author박창일-
dc.contributor.author박해정-
dc.contributor.author오소라-
dc.contributor.author이종두-
dc.contributor.author김철훈-
dc.date.accessioned2014-12-18T09:04:21Z-
dc.date.available2014-12-18T09:04:21Z-
dc.date.issued2013-
dc.identifier.issn0161-5505-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87480-
dc.description.abstractγ-aminobutyric acid (GABA)-A receptor-mediated neural transmission is important to promote practice-dependent plasticity after brain injury. This study investigated alterations in GABA-A receptor binding and functional and anatomic connectivity within the motor cortex in children with cerebral palsy (CP). METHODS: We conducted (18)F-fluoroflumazenil PET on children with hemiplegic CP to investigate whether in vivo GABA-A receptor binding is altered in the ipsilateral or contralateral hemisphere of the lesion site. To evaluate changes in the GABA-A receptor subunit after prenatal brain injury, we performed GABA-A receptor immunohistochemistry using rat pups with a diffuse hypoxic ischemic insult. We also performed diffusion tensor MR imaging and resting-state functional MR imaging on the same children with hemiplegic CP to investigate alterations in anatomic and functional connectivity at the motor cortex with increased GABA-A receptor binding. RESULTS: In children with hemiplegic CP, the (18)F-fluoroflumazenil binding potential was increased within the ipsilateral motor cortex. GABA-A receptors with the α1 subunit were highly expressed exclusively within cortical layers III, IV, and VI of the motor cortex in rat pups. The motor cortex with increased GABA-A receptor binding in children with hemiplegic CP had reduced thalamocortical and corticocortical connectivity, which might be linked to increased GABA-A receptor distribution in cortical layers in rats. CONCLUSION: Increased expression of the GABA-A receptor α1 subunit within the ipsilateral motor cortex may be an important adaptive mechanism after prenatal brain injury in children with CP but may be associated with improper functional connectivity after birth and have adverse effects on the development of motor plasticity.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF NUCLEAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAnimals-
dc.subject.MESHCerebral Palsy/complications-
dc.subject.MESHCerebral Palsy/diagnostic imaging-
dc.subject.MESHCerebral Palsy/metabolism*-
dc.subject.MESHCerebral Palsy/physiopathology-
dc.subject.MESHChild-
dc.subject.MESHFemale-
dc.subject.MESHFlumazenil/analogs & derivatives*-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHHemiplegia/complications*-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMagnetic Resonance Imaging*-
dc.subject.MESHMale-
dc.subject.MESHMotor Cortex/diagnostic imaging-
dc.subject.MESHMotor Cortex/metabolism*-
dc.subject.MESHMotor Cortex/physiopathology-
dc.subject.MESHPositron-Emission Tomography*-
dc.subject.MESHProtein Binding-
dc.subject.MESHRats-
dc.subject.MESHReceptors, GABA-A/metabolism*-
dc.subject.MESHYoung Adult-
dc.titleIncreased GABA-A Receptor Binding and Reduced Connectivity at the Motor Cortex in Children with Hemiplegic Cerebral Palsy: A Multimodal Investigation Using 18F-Fluoroflumazenil PET, Immunohistochemistry, and MR Imaging-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Rehabilitation Medicine (재활의학)-
dc.contributor.googleauthorHae-Jeong Park-
dc.contributor.googleauthorChul Hoon Kim-
dc.contributor.googleauthorEun Sook Park-
dc.contributor.googleauthorBumhee Park-
dc.contributor.googleauthorSo Ra Oh-
dc.contributor.googleauthorMaeng-Keun Oh-
dc.contributor.googleauthorChang Il Park-
dc.contributor.googleauthorJong Doo Lee-
dc.identifier.doi10.2967/jnumed.112.117358-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01472-
dc.contributor.localIdA01611-
dc.contributor.localIdA01717-
dc.contributor.localIdA01730-
dc.contributor.localIdA02380-
dc.contributor.localIdA03138-
dc.contributor.localIdA01057-
dc.relation.journalcodeJ01644-
dc.identifier.eissn1535-5667-
dc.identifier.pmid23785171-
dc.identifier.urlhttp://jnm.snmjournals.org/content/54/8/1263.long-
dc.subject.keywordGABA-A receptor-
dc.subject.keywordcerebral palsy-
dc.subject.keywordconnectivity-
dc.subject.keywordhemiplegic spastic cerebral palsy-
dc.contributor.alternativeNamePark, Bum Hee-
dc.contributor.alternativeNamePark, Eun Sook-
dc.contributor.alternativeNamePark, Chang Il-
dc.contributor.alternativeNamePark, Hae Jeong-
dc.contributor.alternativeNameOh, So Ra-
dc.contributor.alternativeNameLee, Jong Doo-
dc.contributor.alternativeNameKim, Chul Hoon-
dc.contributor.affiliatedAuthorPark, Bum Hee-
dc.contributor.affiliatedAuthorPark, Eun Sook-
dc.contributor.affiliatedAuthorPark, Chang Il-
dc.contributor.affiliatedAuthorPark, Hae Jeong-
dc.contributor.affiliatedAuthorOh, So Ra-
dc.contributor.affiliatedAuthorLee, Jong Doo-
dc.contributor.affiliatedAuthorKim, Chul Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume54-
dc.citation.number8-
dc.citation.startPage1263-
dc.citation.endPage1269-
dc.identifier.bibliographicCitationJOURNAL OF NUCLEAR MEDICINE, Vol.54(8) : 1263-1269, 2013-
dc.identifier.rimsid34253-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.