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Synergistic activation of lipopolysaccharide-stimulated glial cells by propofol

Authors
 Hyun Myung Koa  ;  So Yeon Kim  ;  So Hyun Joo  ;  Jae Hoon Cheong  ;  Sung-Il Yang  ;  Chan Young Shin  ;  Bon Nyeo Koo 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.438(2) : 420-426, 2013 
Journal Title
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
ISSN
 0006-291X 
Issue Date
2013
MeSH
Anesthetics, Intravenous/pharmacology ; Animals ; Astrocytes/cytology ; Cell Death ; Cell Survival ; Cells, Cultured ; Cerebral Cortex/metabolism ; Cytokines/metabolism ; Dose-Response Relationship, Drug ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Lipopolysaccharides/metabolism* ; MAP Kinase Kinase 4/metabolism ; Matrix Metalloproteinase 9/metabolism ; Neuroglia/cytology* ; Neuroglia/drug effects* ; Neurons/cytology ; Neurons/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Propofol/pharmacology* ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species ; p38 Mitogen-Activated Protein Kinases/metabolism
Keywords
Cytokines ; JNK ; Neuronal death ; iNOS ; p38
Abstract
Despite the extensive use of propofol in general anesthetic procedures, the effects of propofol on glial cell were not completely understood. In lipopolysaccharide (LPS)-stimulated rat primary astrocytes and BV2 microglial cell lines, co-treatment of propofol synergistically induced inflammatory activation as evidenced by the increased production of NO, ROS and expression of iNOS, MMP-9 and several cytokines. Propofol augmented the activation of JNK and p38 MAPKs induced by LPS and the synergistic activation of glial cells by propofol was prevented by pretreatment of JNK and p38 inhibitors. When we treated BV2 cell culture supernatants treated with LPS plus propofol on cultured rat primary neuron, it induced a significant neuronal cell death. The results suggest that the repeated use of propofol in immunologically challenged situation may induce glial activation in brain.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X13012515
DOI
10.1016/j.bbrc.2013.07.089
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Koo, Bon-Nyeo(구본녀) ORCID logo https://orcid.org/0000-0002-3189-1673
Kim, So Yeon(김소연) ORCID logo https://orcid.org/0000-0001-5352-157X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87404
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