2 338

Cited 11 times in

Synergistic activation of lipopolysaccharide-stimulated glial cells by propofol

DC Field Value Language
dc.contributor.author구본녀-
dc.contributor.author김소연-
dc.date.accessioned2014-12-18T09:01:58Z-
dc.date.available2014-12-18T09:01:58Z-
dc.date.issued2013-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87404-
dc.description.abstractDespite the extensive use of propofol in general anesthetic procedures, the effects of propofol on glial cell were not completely understood. In lipopolysaccharide (LPS)-stimulated rat primary astrocytes and BV2 microglial cell lines, co-treatment of propofol synergistically induced inflammatory activation as evidenced by the increased production of NO, ROS and expression of iNOS, MMP-9 and several cytokines. Propofol augmented the activation of JNK and p38 MAPKs induced by LPS and the synergistic activation of glial cells by propofol was prevented by pretreatment of JNK and p38 inhibitors. When we treated BV2 cell culture supernatants treated with LPS plus propofol on cultured rat primary neuron, it induced a significant neuronal cell death. The results suggest that the repeated use of propofol in immunologically challenged situation may induce glial activation in brain.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnesthetics, Intravenous/pharmacology-
dc.subject.MESHAnimals-
dc.subject.MESHAstrocytes/cytology-
dc.subject.MESHCell Death-
dc.subject.MESHCell Survival-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCerebral Cortex/metabolism-
dc.subject.MESHCytokines/metabolism-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHInterleukin-1beta/metabolism-
dc.subject.MESHInterleukin-6/metabolism-
dc.subject.MESHLipopolysaccharides/metabolism*-
dc.subject.MESHMAP Kinase Kinase 4/metabolism-
dc.subject.MESHMatrix Metalloproteinase 9/metabolism-
dc.subject.MESHNeuroglia/cytology*-
dc.subject.MESHNeuroglia/drug effects*-
dc.subject.MESHNeurons/cytology-
dc.subject.MESHNeurons/metabolism-
dc.subject.MESHNitric Oxide/metabolism-
dc.subject.MESHNitric Oxide Synthase Type II/metabolism-
dc.subject.MESHPropofol/pharmacology*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReactive Oxygen Species-
dc.subject.MESHp38 Mitogen-Activated Protein Kinases/metabolism-
dc.titleSynergistic activation of lipopolysaccharide-stimulated glial cells by propofol-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorHyun Myung Koa-
dc.contributor.googleauthorSo Yeon Kim-
dc.contributor.googleauthorSo Hyun Joo-
dc.contributor.googleauthorJae Hoon Cheong-
dc.contributor.googleauthorSung-Il Yang-
dc.contributor.googleauthorChan Young Shin-
dc.contributor.googleauthorBon Nyeo Koo-
dc.identifier.doi10.1016/j.bbrc.2013.07.089-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00193-
dc.contributor.localIdA00616-
dc.relation.journalcodeJ00281-
dc.identifier.eissn1090-2104-
dc.identifier.pmid23899524-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0006291X13012515-
dc.subject.keywordCytokines-
dc.subject.keywordJNK-
dc.subject.keywordNeuronal death-
dc.subject.keywordiNOS-
dc.subject.keywordp38-
dc.contributor.alternativeNameKu, Bon Nyo-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.affiliatedAuthorKu, Bon Nyo-
dc.contributor.affiliatedAuthorKim, So Yeon-
dc.rights.accessRightsnot free-
dc.citation.volume438-
dc.citation.number2-
dc.citation.startPage420-
dc.citation.endPage426-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.438(2) : 420-426, 2013-
dc.identifier.rimsid33036-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.