Cited 13 times in
Synergistic activation of lipopolysaccharide-stimulated glial cells by propofol
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구본녀 | - |
dc.contributor.author | 김소연 | - |
dc.date.accessioned | 2014-12-18T09:01:58Z | - |
dc.date.available | 2014-12-18T09:01:58Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87404 | - |
dc.description.abstract | Despite the extensive use of propofol in general anesthetic procedures, the effects of propofol on glial cell were not completely understood. In lipopolysaccharide (LPS)-stimulated rat primary astrocytes and BV2 microglial cell lines, co-treatment of propofol synergistically induced inflammatory activation as evidenced by the increased production of NO, ROS and expression of iNOS, MMP-9 and several cytokines. Propofol augmented the activation of JNK and p38 MAPKs induced by LPS and the synergistic activation of glial cells by propofol was prevented by pretreatment of JNK and p38 inhibitors. When we treated BV2 cell culture supernatants treated with LPS plus propofol on cultured rat primary neuron, it induced a significant neuronal cell death. The results suggest that the repeated use of propofol in immunologically challenged situation may induce glial activation in brain. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anesthetics, Intravenous/pharmacology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Astrocytes/cytology | - |
dc.subject.MESH | Cell Death | - |
dc.subject.MESH | Cell Survival | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Cerebral Cortex/metabolism | - |
dc.subject.MESH | Cytokines/metabolism | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Interleukin-1beta/metabolism | - |
dc.subject.MESH | Interleukin-6/metabolism | - |
dc.subject.MESH | Lipopolysaccharides/metabolism* | - |
dc.subject.MESH | MAP Kinase Kinase 4/metabolism | - |
dc.subject.MESH | Matrix Metalloproteinase 9/metabolism | - |
dc.subject.MESH | Neuroglia/cytology* | - |
dc.subject.MESH | Neuroglia/drug effects* | - |
dc.subject.MESH | Neurons/cytology | - |
dc.subject.MESH | Neurons/metabolism | - |
dc.subject.MESH | Nitric Oxide/metabolism | - |
dc.subject.MESH | Nitric Oxide Synthase Type II/metabolism | - |
dc.subject.MESH | Propofol/pharmacology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reactive Oxygen Species | - |
dc.subject.MESH | p38 Mitogen-Activated Protein Kinases/metabolism | - |
dc.title | Synergistic activation of lipopolysaccharide-stimulated glial cells by propofol | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Hyun Myung Koa | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.contributor.googleauthor | So Hyun Joo | - |
dc.contributor.googleauthor | Jae Hoon Cheong | - |
dc.contributor.googleauthor | Sung-Il Yang | - |
dc.contributor.googleauthor | Chan Young Shin | - |
dc.contributor.googleauthor | Bon Nyeo Koo | - |
dc.identifier.doi | 10.1016/j.bbrc.2013.07.089 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00193 | - |
dc.contributor.localId | A00616 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 23899524 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X13012515 | - |
dc.subject.keyword | Cytokines | - |
dc.subject.keyword | JNK | - |
dc.subject.keyword | Neuronal death | - |
dc.subject.keyword | iNOS | - |
dc.subject.keyword | p38 | - |
dc.contributor.alternativeName | Ku, Bon Nyo | - |
dc.contributor.alternativeName | Kim, So Yeon | - |
dc.contributor.affiliatedAuthor | Ku, Bon Nyo | - |
dc.contributor.affiliatedAuthor | Kim, So Yeon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 438 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 420 | - |
dc.citation.endPage | 426 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.438(2) : 420-426, 2013 | - |
dc.identifier.rimsid | 33036 | - |
dc.type.rims | ART | - |
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