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Risk Factors for Neurologic Complications of Hand, Foot and Mouth Disease in the Republic of Korea, 2009

 Seong Joon Kim  ;  Jong-Hyun Kim  ;  Jin-Han Kang  ;  Dong Soo Kim  ;  Ki Hwan Kim  ;  Kyung-Hyo Kim  ;  Young-Hoon Kim  ;  Ju-Young Chung  ;  Joong Hyun Bin  ;  Da Eun Jung  ;  Ji Hong Kim  ;  Hwang Min Kim  ;  Doo-Sung Cheon  ;  Byung Hak Kang  ;  Soon Young Seo 
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.28(1) : 120-127, 2013 
Journal Title
Issue Date
Adolescent ; Adult ; Blood Glucose/analysis ; Body Temperature ; Enterovirus A, Human/genetics ; Enterovirus A, Human/isolation & purification ; Female ; Fever/etiology ; Genotype ; Hand, Foot and Mouth Disease/complications* ; Hand, Foot and Mouth Disease/virology ; Headache/etiology ; Herpangina/complications* ; Herpangina/virology ; Humans ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Republic of Korea ; Retrospective Studies ; Risk Factors ; Vomiting/etiology ; Young Adult
Coxsackievirus ; Enterovirus A, Human ; Hand, Foot and Mouth Disease ; Herpangina ; Risk Factors
In 2009, the first outbreak of hand, foot and mouth disease (HFMD) or herpangina (HP) caused by enterovirus 71 occurred in the Republic of Korea. This study inquired into risk factors associated with complications of HFMD or HP. A retrospective medical records review was conducted on HFMD or HP patients for whom etiologic viruses had been verified in 2009. One hundred sixty-eight patients were examined for this investigation. Eighty patients were without complications while 88 were accompanied by complications, and 2 had expired. Enterovirus 71 subgenotype C4a was the most prevalent in number with 67 cases (54.9%). In the univariate analysis, the disease patterns of HFMD rather than HP, fever longer than 4 days, peak body temperature over 39℃, vomiting, headache, neurologic signs, serum glucose over 100 mg/dL, and having an enterovirus 71 as a causative virus were significant risk factors of the complications. After multiple logistic analysis, headache (Odds ratio [OR], 10.75; P < 0.001) and neurologic signs (OR, 42.76; P < 0.001) were found to be the most significant factors. Early detection and proper management of patients with aforementioned risk factors would be necessary in order to attain a better clinical outcome.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Hwan(김기환)
Kim, Dong Soo(김동수)
Kim, Ji Hong(김지홍) ORCID logo https://orcid.org/0000-0001-5352-5423
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