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Mortality prediction of rats in acute hemorrhagic shock using machine learning techniques

Other Titles
 기계학습방법을 이용한 백서에서의 급성 출혈성쇼크의 사망예측 
Authors
 Kyung-Ah Kim  ;  Joon Yul Choi  ;  Tae Keun Yoo  ;  Sung Kean Kim  ;  KilSoo Chung  ;  Deok Won Kim 
Citation
 MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, Vol.51(9) : 1059-1067, 2013 
Journal Title
 MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING 
ISSN
 0140-0118 
Issue Date
2013
MeSH
Animals ; Artificial Intelligence* ; Body Temperature ; Hemodynamics/physiology ; Lactic Acid/blood ; Logistic Models ; Male ; Models, Statistical* ; ROC Curve ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Respiratory Rate/physiology ; Shock, Hemorrhagic/physiopathology* ; Statistics, Nonparametric ; Support Vector Machine
Keywords
Hemorrhagic shock ; Rat ; Mortality ; Machine learning ; Support vector machine
Abstract
This study sought to determine a mortality prediction model that could be used for triage in the setting of acute hemorrhage from trauma. To achieve this aim, various machine learning techniques were applied using the rat model in acute hemorrhage. Thirty-six anesthetized rats were randomized into three groups according to the volume of controlled blood loss. Measurements included heart rate (HR), systolic and diastolic blood pressures (SBP and DBP), mean arterial pressure, pulse pressure, respiratory rate, temperature, blood lactate concentration (LC), peripheral perfusion (PP), shock index (SI, SI = HR/SBP), and a new hemorrhage-induced severity index (NI, NI = LC/PP). NI was suggested as one of the good candidates for mortality prediction variable in our previous study. We constructed mortality prediction models with logistic regression (LR), artificial neural networks (ANN), random forest (RF), and support vector machines (SVM) with variable selection. The SVM model showed better sensitivity (1.000) and area under curve (0.972) than the LR, ANN, and RF models for mortality prediction. The important variables selected by the SVM were NI and LC. The SVM model may be very helpful to first responders who need to make accurate triage decisions and rapidly treat hemorrhagic patients in cases of trauma.
Full Text
http://link.springer.com/article/10.1007%2Fs11517-013-1091-0
DOI
10.1007/s11517-013-1091-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Deok Won(김덕원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87381
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