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Extent of Late Gadolinium Enhancement on Cardiovascular Magnetic Resonance Imaging and Its Relation to Left Ventricular Longitudinal Functional Reserve During Exercise in Patients With Hypertrophic Cardiomyopathy

DC Field Value Language
dc.contributor.author김영진-
dc.contributor.author심지영-
dc.contributor.author장양수-
dc.contributor.author정남식-
dc.contributor.author조승연-
dc.contributor.author하종원-
dc.contributor.author홍유진-
dc.date.accessioned2014-12-18T08:58:32Z-
dc.date.available2014-12-18T08:58:32Z-
dc.date.issued2013-
dc.identifier.issn1346-9843-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87301-
dc.description.abstractBACKGROUND: The aim of this study was to investigate whether the extent of late gadolinium enhancement (LGE) on cardiovascular magnetic resonance imaging reflecting myocardial fibrosis correlates with left ventricular (LV) longitudinal function during exercise in hypertrophic cardiomyopathy (HCM). METHODS AND RESULTS: Mitral annular velocities (E' and S') were measured on echocardiography at rest and during graded bicycle exercise (25 W, 3-min increments) in 46 HCM patients (mean age, 53 years; 32 men). LV longitudinal diastolic and systolic functional reserve indices were calculated as ΔE'×E'base and ΔS'×S'base, where ΔE' and ΔS' are the changes in E' and S' from baseline to 50 W of exercise, respectively. The patients were divided into 2 groups according to the extent of LGE (as "percentage of LV mass containing LGE": %LV with LGE; range, 0-37%; median, 6%): group 1 (n=23), %LV with LGE <6%, and group 2, %LV with LGE ≥6%. Baseline echocardiographic parameters were similar between the 2 groups, but changes in E' and S' during exercise were smaller in group 2 (ΔE': 2.8±1.8 cm/s vs.1.5±1.0 cm/s, P=0.007; ΔS': 2.2±1.2 cm/s vs. 0.9±0.8 cm/s, P<0.0001). LV functional reserve indices were also significantly lower in group 2 (ΔE'×E'(base): 12.8±7.7 vs. 5.5±3.4, P=0.001; ΔS'×S'(base): 12.6±7.4 vs. 4.7±4.5, P<0.0001). CONCLUSIONS: LV longitudinal function during exercise is influenced by the extent of LGE in HCM. Myocardial fibrosis may represent a pathologic substrate that determines LV functional reserve in patients with HCM.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCIRCULATION JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCardiomegaly*/diagnostic imaging-
dc.subject.MESHCardiomegaly*/physiopathology-
dc.subject.MESHContrast Media/administration & dosage*-
dc.subject.MESHExercise*-
dc.subject.MESHFemale-
dc.subject.MESHGadolinium/administration & dosage*-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging/methods*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRadiography-
dc.subject.MESHVentricular Function, Left*-
dc.titleExtent of Late Gadolinium Enhancement on Cardiovascular Magnetic Resonance Imaging and Its Relation to Left Ventricular Longitudinal Functional Reserve During Exercise in Patients With Hypertrophic Cardiomyopathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJeonggeun Moon-
dc.contributor.googleauthorYoo Jin Hong-
dc.contributor.googleauthorYoung-Jin Kim-
dc.contributor.googleauthorChi Young Shim-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorNamsik Chung-
dc.contributor.googleauthorSeung-Yun Cho-
dc.contributor.googleauthorJong-Won Ha-
dc.identifier.doi10.1253/circj.CJ-12-1378-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02213-
dc.contributor.localIdA03448-
dc.contributor.localIdA03585-
dc.contributor.localIdA03844-
dc.contributor.localIdA04257-
dc.contributor.localIdA04422-
dc.contributor.localIdA00727-
dc.relation.journalcodeJ00534-
dc.identifier.eissn1347-4820-
dc.identifier.pmid23546472-
dc.subject.keywordEchocardiography-
dc.subject.keywordExercise-
dc.subject.keywordHypertrophic cardiomyopathy-
dc.subject.keywordLeft ventricular function-
dc.subject.keywordMagnetic resonance imaging-
dc.contributor.alternativeNameKim, Young Jin-
dc.contributor.alternativeNameShim, Chi Young-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameCho, Seung Yun-
dc.contributor.alternativeNameHa, Jong Won-
dc.contributor.alternativeNameHong, Yoo Jin-
dc.contributor.affiliatedAuthorShim, Chi Young-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorCho, Seung Yun-
dc.contributor.affiliatedAuthorHa, Jong Won-
dc.contributor.affiliatedAuthorHong, Yoo Jin-
dc.contributor.affiliatedAuthorKim, Young Jin-
dc.rights.accessRightsfree-
dc.citation.volume77-
dc.citation.number7-
dc.citation.startPage1742-
dc.citation.endPage1749-
dc.identifier.bibliographicCitationCIRCULATION JOURNAL, Vol.77(7) : 1742-1749, 2013-
dc.identifier.rimsid32962-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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