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Usefulness of impulse oscillometry and fractional exhaled nitric oxide in children with Eosinophilic bronchitis

Authors
 Yoon Hee Kim ; Kyung Won Kim ; Kyu-Earn Kim ; Myung Hyun Sohn ; Jae Myun Lee ; Kyung-Joo Song ; Hyemi Kim ; Hyun Bin Park ; Jiyoung Baek 
Citation
 Pediatric Pulmonology, Vol.48(3) : 221~228, 2013 
Journal Title
 Pediatric Pulmonology 
ISSN
 8755-6863 
Issue Date
2013
Abstract
BACKGROUND: Eosinophilic bronchitis (EB) is a common cause of chronic cough. Although EB shares many immunopathologic features with asthma, it does not show airway hyperresponsiveness or reversible airway obstruction by spirometry. OBJECTIVE: Compared to healthy children without pulmonary disease, we hypothesized that EB patients would demonstrate abnormal pulmonary function and inflammation with impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO), which are more sensitive tests of these parameters than spirometry. METHODS: A total of 232 children with asthma, 109 with EB, and 115 control subjects were enrolled. We compared pulmonary function parameters and FeNO levels among the three groups. Additionally, we designated a screening cutoff value of FeNO combined with IOS parameters to distinguish EB from the control group, and identify which children with EB have more asthmatic characteristics. RESULTS: By IOS, the bronchodilator response of the EB and asthma groups increased significantly compared to controls for both reactance at 5 Hz (Δ X5) and reactance area (Δ AX) (P < 0.0001). Cutoff values to distinguish EB from controls were a Δ X5 of -20% (sensitivity, 77.5%; specificity, 49.6%), and Δ AX of -30% (sensitivity, 75.0%; specificity, 46.0%), when the FeNO is 20 ppb. CONCLUSIONS: Reversible airway obstruction in IOS and elevated FeNO levels can be detected in children with EB. This would support that EB in children shows airway characteristics similar to those of asthma, and that a continuum exists between asthma and EB.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/87230
DOI
10.1002/ppul.22631
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/ppul.22631/abstract
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