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Comparison of the Efficacy of Dexmedetomidine plus Fentanyl Patient-controlled Analgesia with Fentanyl Patient-controlled Analgesia for Pain Control in Uterine Artery Embolization for Symptomatic Fibroid Tumors or Adenomyosis: A Prospective, Randomized Study

DC FieldValueLanguage
dc.contributor.author김만득-
dc.contributor.author김소연-
dc.contributor.author이종석-
dc.contributor.author장철호-
dc.contributor.author한동우-
dc.date.accessioned2014-12-18T08:54:26Z-
dc.date.available2014-12-18T08:54:26Z-
dc.date.issued2013-
dc.identifier.issn1051-0443-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87171-
dc.description.abstractPURPOSE: To investigate whether dexmedetomidine infusion could reduce opioid consumption and opioid-related side effects after uterine artery embolization (UAE). MATERIALS AND METHODS: Fifty patients undergoing UAE for symptomatic leiomyomas or adenomyosis were randomized into two groups. In 25 patients, dexmedetomidine infusion was started at 0.2 μg/kg/h at 30 minutes before the procedure, followed by 0.4 μg/kg/h for 6 hours after the procedure. In another 25 patients (control group), volume-matched normal saline solution was administered. Both groups received fentanyl-based intravenous patient-controlled analgesia (PCA; fentanyl 10 μg/h with a bolus dose of 20 μg) during the 24 hours after the procedure. Nonspherical polyvinyl alcohol particles were used. Pain scores, fentanyl consumption, need for additional analgesics, and side effects were assessed for 24 hours after UAE. RESULTS: Compared with the control group, patients in the dexmedetomidine group required 28% less PCA fentanyl during the 24 hours after UAE (P = .006). Numeric rating scale scores for pain (5.0±2.4 vs 7.0±2.2; P = .026) and the need for additional analgesics (two of 25 vs 17 of 25; P<.001) were lower in the dexmedetomidine group than in the control group during the first 1 hour after UAE. The incidence and severity of nausea and vomiting during the 24 hours after UAE were lower in the dexmedetomidine group than in the control group (P < .05). CONCLUSIONS: The addition of dexmedetomidine infusion to fentanyl PCA provides better analgesia, fentanyl-sparing effect, and less nausea and vomiting, without significant hemodynamic instability.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJournal of Vascular and Interventional Radiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleComparison of the Efficacy of Dexmedetomidine plus Fentanyl Patient-controlled Analgesia with Fentanyl Patient-controlled Analgesia for Pain Control in Uterine Artery Embolization for Symptomatic Fibroid Tumors or Adenomyosis: A Prospective, Randomized Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorSo Yeon Kim-
dc.contributor.googleauthorChul Ho Chang-
dc.contributor.googleauthorJong Seok Lee-
dc.contributor.googleauthorYoon Jae Kim-
dc.contributor.googleauthorMan Deuk Kim-
dc.contributor.googleauthorDong Woo Han-
dc.identifier.doi10.1016/j.jvir.2013.02.034-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00420-
dc.contributor.localIdA03485-
dc.contributor.localIdA04274-
dc.contributor.localIdA03141-
dc.contributor.localIdA00616-
dc.relation.journalcodeJ01922-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1051044313007227-
dc.contributor.alternativeNameKim, Man Deuk-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.alternativeNameLee, Jong Seok-
dc.contributor.alternativeNameChang, Chul Ho-
dc.contributor.alternativeNameHan, Dong Woo-
dc.contributor.affiliatedAuthorKim, Man Deuk-
dc.contributor.affiliatedAuthorChang, Chul Ho-
dc.contributor.affiliatedAuthorHan, Dong Woo-
dc.contributor.affiliatedAuthorLee, Jong Seok-
dc.contributor.affiliatedAuthorKim, So Yeon-
dc.rights.accessRightsnot free-
dc.citation.volume24-
dc.citation.number6-
dc.citation.startPage779-
dc.citation.endPage786-
dc.identifier.bibliographicCitationJournal of Vascular and Interventional Radiology, Vol.24(6) : 779-786, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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