Cited 6 times in
Erythropoietin Prevents Hypoxia-Induced GATA-4 Ubiquitination via Phosphorylation of Serine 105 of GATA-4
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽영란 | - |
dc.contributor.author | 김지호 | - |
dc.contributor.author | 신은정 | - |
dc.contributor.author | 심재광 | - |
dc.contributor.author | 전지혜 | - |
dc.date.accessioned | 2014-12-18T08:54:18Z | - |
dc.date.available | 2014-12-18T08:54:18Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87167 | - |
dc.description.abstract | Erythropoietin (EPO), an essential hormone for erythropoiesis, can provide protection against myocardial ischemia/reperfusion (I/R) injury and hypoxic apoptosis. GATA-4 is a zinc finger transcription factor, and its activation and post-translational modification are essential components in the transcriptional response to hypoxia. GATA-4 has also been reported to play a role in the cellular mechanisms of EPO-induced myocardial protection against I/R injury. In this study, we aimed to investigate the influence of EPO on GATA-4 protein stability and post-translational modification under hypoxic conditions without reperfusion. EPO induced cell viability under long-term hypoxia. EPO significantly increased phosphorylation of GATA-4 via the extracellular signal-regulated kinase (ERK) signaling pathway and reduced hypoxia-induced GATA-4 ubiquitination, which enhanced GATA-4 stability under hypoxia. ERK activation by over-expression of constitutively active mitogen-activated protein kinase 1 (MEK1) strongly increased GATA-4 phosphorylation and its protein levels and decreased GATA-4 ubiquitination under hypoxia. Despite ERK activation, GATA-4 ubiquitination was not affected under hypoxia in a GATA-4-S105A mutant. Under hypoxic condition without reperfusion, EPO-induced ERK activation was associated with post-translational modification of GATA-4, mediated by enhancement of phosphorylation of GATA-4 at Ser-105. Subsequent attenuation of GATA-4 ubiquitination led to increases in GATA-4 protein stability, which resulted in increased cell viability under hypoxia. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Erythropoietin Prevents Hypoxia-Induced GATA-4 Ubiquitination via Phosphorylation of Serine 105 of GATA-4 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Ji Hae Jun | - |
dc.contributor.googleauthor | Eun Jung Shin | - |
dc.contributor.googleauthor | Ji Ho Kim | - |
dc.contributor.googleauthor | Si Oh Kim | - |
dc.contributor.googleauthor | Jae-Kwang Shim | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.identifier.doi | 10.1248/bpb.b13-00100 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A01002 | - |
dc.contributor.localId | A02135 | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A03551 | - |
dc.relation.journalcode | J00300 | - |
dc.identifier.eissn | 1347-5215 | - |
dc.identifier.pmid | erythropoietin ; hypoxia ; Ser-105 ; GATA-4 ; phosphorylation ; ubiquitination | - |
dc.subject.keyword | erythropoietin | - |
dc.subject.keyword | hypoxia | - |
dc.subject.keyword | Ser-105 | - |
dc.subject.keyword | GATA-4 | - |
dc.subject.keyword | phosphorylation | - |
dc.subject.keyword | ubiquitination | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.alternativeName | Kim, Ji Ho | - |
dc.contributor.alternativeName | Shin, Eun Jung | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.alternativeName | Jun, Ji Hae | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Kim, Ji Ho | - |
dc.contributor.affiliatedAuthor | Shin, Eun Jung | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Jun, Ji Hae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 36 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1126 | - |
dc.citation.endPage | 1133 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, Vol.36(7) : 1126-1133, 2013 | - |
dc.identifier.rimsid | 32533 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.