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Immunosenescent CD8+ T Cells and C-X-C Chemokine Receptor Type 3 Chemokines Are Increased in Human Hypertension.

Authors
 Jong-Chan Youn  ;  Hee Tae Yu  ;  Beom Jin Lim  ;  Myoung Ju Koh  ;  Jino Lee  ;  Dong-Yeop Chang  ;  Yoon Seok Choi  ;  Sang-Hak Lee  ;  Seok-Min Kang  ;  Yangsoo Jang  ;  Ook Joon Yoo  ;  Eui-Cheol Shin  ;  Sungha Park 
Citation
 HYPERTENSION, Vol.62(1) : 126-133, 2013 
Journal Title
 HYPERTENSION 
ISSN
 0194-911X 
Issue Date
2013
MeSH
CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism* ; CD8-Positive T-Lymphocytes/pathology ; Chemotaxis, Leukocyte/immunology* ; Female ; Flow Cytometry ; Humans ; Hypertension/immunology ; Hypertension/metabolism* ; Hypertension/pathology ; Immunity, Cellular* ; Immunohistochemistry ; Male ; Middle Aged ; Prospective Studies ; Receptors, CXCR3/biosynthesis*
Keywords
T cell ; aging ; chemokine ; hypertension ; inflammation
Abstract
The pathogenic role of T cells in hypertension has been documented well in recent animal studies. However, the existence of T-cell-driven inflammation in human hypertension has not been confirmed. Therefore, we undertook immunologic characterization of T cells from patients with hypertension and measured circulating levels of C-X-C chemokine receptor type 3 chemokines, which are well-known tissue-homing chemokines for T cells. We analyzed immunologic markers on T cells from patients with hypertension by multicolor flow cytometry. We then measured circulating levels of the C-X-C chemokine receptor type 3 chemokines, monokine induced by γ interferon (IFN), IFN γ-induced protein 10, and IFN-inducible T-cell α chemoattractant, in patients with hypertension and in age- and sex-matched control subjects by the cytometric bead array method. In addition, we examined histological features of IFN-inducible T-cell α chemoattractant expression from renal biopsy specimens of patients with hypertensive nephrosclerosis and control subjects. The total T-cell population from patients with hypertension showed an increased fraction of immunosenescent, proinflammatory, cytotoxic CD8(+) T cells. Circulating levels of C-X-C chemokine receptor type 3 chemokines were significantly higher in patients with hypertension than in control subjects. Furthermore, immunohistochemical staining revealed increased expression of the T-cell chemokine, IFN-inducible T-cell α chemoattractant, in the proximal and distal tubules of patients with hypertensive nephrosclerosis. Immunosenescent CD8(+) T cells and C-X-C chemokine receptor type 3 chemokines are increased in human hypertension, suggesting a role for T-cell-driven inflammation in hypertension. A more detailed characterization of CD8(+) T cells may offer new opportunities for the prevention and treatment of human hypertension.
Full Text
http://hyper.ahajournals.org/content/62/1/126.long
DOI
10.1161/HYPERTENSIONAHA.113.00689
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Yu, Hee Tae(유희태) ORCID logo https://orcid.org/0000-0002-6835-4759
Youn, Jong Chan(윤종찬)
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Lim, Beom Jin(임범진) ORCID logo https://orcid.org/0000-0003-2856-0133
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87145
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