Cited 19 times in
The Impact of Cigarette Smoking on the Frequency of and Qualitative Differences in KRAS Mutations in Korean Patients with Lung Adenocarcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조병철 | - |
dc.contributor.author | 홍윤경 | - |
dc.contributor.author | 김주항 | - |
dc.contributor.author | 김혜련 | - |
dc.contributor.author | 남기창 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 안정련 | - |
dc.contributor.author | 이진구 | - |
dc.date.accessioned | 2014-12-18T08:53:14Z | - |
dc.date.available | 2014-12-18T08:53:14Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87133 | - |
dc.description.abstract | PURPOSE: This study was designed to determine the relationship of cigarette smoking to the frequency and qualitative differences among KRAS mutations in lung adenocarcinomas from Korean patients. MATERIALS AND METHODS: Detailed smoking histories were obtained from 200 consecutively enrolled patients with lung adenocarcinoma according to a standard protocol. EGFR (exons 18 to 21) and KRAS (codons 12/13) mutations were determined via direct-sequencing. RESULTS: The incidence of KRAS mutations was 8% (16 of 200) in patients with lung adenocarcinoma. KRAS mutations were found in 5.8% (7 of 120) of tumors from never-smokers, 15% (6 of 40) from former-smokers, and 7.5% (3 of 40) from current-smokers. The frequency of KRAS mutations did not differ significantly according to smoking history (p=0.435). Never-smokers were significantly more likely than former or current smokers to have a transition mutation (G→A or C→T) rather than a transversion mutation (G→T or G→C) that is known to be smoking-related (p=0.011). In a Cox regression model, the adjusted hazard ratios for the risk of progression with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) were 0.24 (95% CI, 0.14-0.42; p<0.001) for the EGFR mutation and 1.27 (95% CI, 0.58-2.79; p=0.537) for the KRAS mutation. CONCLUSION: Cigarette smoking did not influence the frequency of KRAS mutations in lung adenocarcinomas in Korean patients, but influenced qualitative differences in the KRAS mutations. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/drug therapy | - |
dc.subject.MESH | Adenocarcinoma/etiology | - |
dc.subject.MESH | Adenocarcinoma/genetics* | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Lung Neoplasms/drug therapy | - |
dc.subject.MESH | Lung Neoplasms/etiology | - |
dc.subject.MESH | Lung Neoplasms/genetics* | - |
dc.subject.MESH | Lung Neoplasms/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation* | - |
dc.subject.MESH | Mutation Rate | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Proto-Oncogene Proteins/genetics* | - |
dc.subject.MESH | Proto-Oncogene Proteins p21(ras) | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/antagonists & inhibitors | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/genetics | - |
dc.subject.MESH | Smoking/adverse effects | - |
dc.subject.MESH | Smoking/genetics* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | ras Proteins/genetics* | - |
dc.title | The Impact of Cigarette Smoking on the Frequency of and Qualitative Differences in KRAS Mutations in Korean Patients with Lung Adenocarcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hye Ryun Kim | - |
dc.contributor.googleauthor | Jung Ryun Ahn | - |
dc.contributor.googleauthor | Jin Gu Lee | - |
dc.contributor.googleauthor | Doo Hee Bang | - |
dc.contributor.googleauthor | Sang-Jun Ha | - |
dc.contributor.googleauthor | Yun Kyoung Hong | - |
dc.contributor.googleauthor | Sun Mi Kim | - |
dc.contributor.googleauthor | Ki Chang Nam | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Ross A. Soo | - |
dc.contributor.googleauthor | Gregory J. Riely | - |
dc.contributor.googleauthor | Joo Hang Kim | - |
dc.contributor.googleauthor | Byoung Chul Cho | - |
dc.identifier.doi | 10.3349/ymj.2013.54.4.865 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03822 | - |
dc.contributor.localId | A04423 | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A01166 | - |
dc.contributor.localId | A01242 | - |
dc.contributor.localId | A02256 | - |
dc.contributor.localId | A03225 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 23709419 | - |
dc.subject.keyword | EGFR | - |
dc.subject.keyword | KRAS | - |
dc.subject.keyword | pulmonary adenocarcinoma | - |
dc.subject.keyword | cigarette smoking | - |
dc.subject.keyword | EGFR-tyrosine kinase inhibitors | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.alternativeName | Hong, Yun Kyoung | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.alternativeName | Kim, Hye Ryun | - |
dc.contributor.alternativeName | Nam, Ki Chang | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Ahn, Jung Ryun | - |
dc.contributor.alternativeName | Lee, Jin Gu | - |
dc.contributor.affiliatedAuthor | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Hong, Yun Kyoung | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | Kim, Hye Ryun | - |
dc.contributor.affiliatedAuthor | Nam, Ki Chang | - |
dc.contributor.affiliatedAuthor | Ahn, Jung Ryun | - |
dc.contributor.affiliatedAuthor | Lee, Jin Gu | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 54 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 865 | - |
dc.citation.endPage | 874 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.54(4) : 865-874, 2013 | - |
dc.identifier.rimsid | 32512 | - |
dc.type.rims | ART | - |
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