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The Impact of Cigarette Smoking on the Frequency of and Qualitative Differences in KRAS Mutations in Korean Patients with Lung Adenocarcinoma

DC FieldValueLanguage
dc.contributor.author조병철-
dc.contributor.author홍윤경-
dc.contributor.author김주항-
dc.contributor.author김혜련-
dc.contributor.author남기창-
dc.contributor.author라선영-
dc.contributor.author안정련-
dc.contributor.author이진구-
dc.date.accessioned2014-12-18T08:53:14Z-
dc.date.available2014-12-18T08:53:14Z-
dc.date.issued2013-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87133-
dc.description.abstractPURPOSE: This study was designed to determine the relationship of cigarette smoking to the frequency and qualitative differences among KRAS mutations in lung adenocarcinomas from Korean patients. MATERIALS AND METHODS: Detailed smoking histories were obtained from 200 consecutively enrolled patients with lung adenocarcinoma according to a standard protocol. EGFR (exons 18 to 21) and KRAS (codons 12/13) mutations were determined via direct-sequencing. RESULTS: The incidence of KRAS mutations was 8% (16 of 200) in patients with lung adenocarcinoma. KRAS mutations were found in 5.8% (7 of 120) of tumors from never-smokers, 15% (6 of 40) from former-smokers, and 7.5% (3 of 40) from current-smokers. The frequency of KRAS mutations did not differ significantly according to smoking history (p=0.435). Never-smokers were significantly more likely than former or current smokers to have a transition mutation (G→A or C→T) rather than a transversion mutation (G→T or G→C) that is known to be smoking-related (p=0.011). In a Cox regression model, the adjusted hazard ratios for the risk of progression with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) were 0.24 (95% CI, 0.14-0.42; p<0.001) for the EGFR mutation and 1.27 (95% CI, 0.58-2.79; p=0.537) for the KRAS mutation. CONCLUSION: Cigarette smoking did not influence the frequency of KRAS mutations in lung adenocarcinomas in Korean patients, but influenced qualitative differences in the KRAS mutations.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/drug therapy-
dc.subject.MESHAdenocarcinoma/etiology-
dc.subject.MESHAdenocarcinoma/genetics*-
dc.subject.MESHAdenocarcinoma/pathology-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAsian Continental Ancestry Group/genetics-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHLung Neoplasms/drug therapy-
dc.subject.MESHLung Neoplasms/etiology-
dc.subject.MESHLung Neoplasms/genetics*-
dc.subject.MESHLung Neoplasms/pathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation*-
dc.subject.MESHMutation Rate-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProto-Oncogene Proteins/genetics*-
dc.subject.MESHProto-Oncogene Proteins p21(ras)-
dc.subject.MESHReceptor, Epidermal Growth Factor/antagonists & inhibitors-
dc.subject.MESHReceptor, Epidermal Growth Factor/genetics-
dc.subject.MESHSmoking/adverse effects-
dc.subject.MESHSmoking/genetics*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHras Proteins/genetics*-
dc.titleThe Impact of Cigarette Smoking on the Frequency of and Qualitative Differences in KRAS Mutations in Korean Patients with Lung Adenocarcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHye Ryun Kim-
dc.contributor.googleauthorJung Ryun Ahn-
dc.contributor.googleauthorJin Gu Lee-
dc.contributor.googleauthorDoo Hee Bang-
dc.contributor.googleauthorSang-Jun Ha-
dc.contributor.googleauthorYun Kyoung Hong-
dc.contributor.googleauthorSun Mi Kim-
dc.contributor.googleauthorKi Chang Nam-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorRoss A. Soo-
dc.contributor.googleauthorGregory J. Riely-
dc.contributor.googleauthorJoo Hang Kim-
dc.contributor.googleauthorByoung Chul Cho-
dc.identifier.doi10.3349/ymj.2013.54.4.865-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03822-
dc.contributor.localIdA04423-
dc.contributor.localIdA00945-
dc.contributor.localIdA01166-
dc.contributor.localIdA01242-
dc.contributor.localIdA02256-
dc.contributor.localIdA03225-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid23709419-
dc.subject.keywordEGFR-
dc.subject.keywordKRAS-
dc.subject.keywordpulmonary adenocarcinoma-
dc.subject.keywordcigarette smoking-
dc.subject.keywordEGFR-tyrosine kinase inhibitors-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.alternativeNameHong, Yun Kyoung-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameKim, Hye Ryun-
dc.contributor.alternativeNameNam, Ki Chang-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameAhn, Jung Ryun-
dc.contributor.alternativeNameLee, Jin Gu-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.contributor.affiliatedAuthorHong, Yun Kyoung-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorKim, Hye Ryun-
dc.contributor.affiliatedAuthorNam, Ki Chang-
dc.contributor.affiliatedAuthorAhn, Jung Ryun-
dc.contributor.affiliatedAuthorLee, Jin Gu-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.rights.accessRightsfree-
dc.citation.volume54-
dc.citation.number4-
dc.citation.startPage865-
dc.citation.endPage874-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.54(4) : 865-874, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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