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Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography

 Ryo Nakazato ; Heidi Gransar ; James K. Min ; Jonathon Leipsic ; Yong-Jin Kim ; Gudrun Feuchtner ; Ricardo C. Cury ; Allison Dunning ; Todd C. Villines ; Leslee J. Shaw ; Gilbert Raff ; Erica Maffei ; Philipp Kaufmann ; Joerg Hausleiter ; Martin Hadamitzky ; Augustin Delago ; Benjamin J.W. Chow ; Kavitha Chinnaiyan ; Hyuk-Jae Chang ; Tracy Q. Callister ; Filippo Cademartiri ; Matthew J. Budoff ; Mouaz Al-Mallah ; Stephan Achenbach ; Fay Y. Lin ; Victor Y. Cheng ; Daniel S. Berman 
 Journal of Cardiovascular Computed Tomography, Vol.7(2) : 83~90, 2013 
Journal Title
 Journal of Cardiovascular Computed Tomography 
Issue Date
BACKGROUND: The association between lipoprotein levels and coronary plaque composition is not well understood. OBJECTIVE: The aim of this prospective international multicenter study of statin-naive individuals was to evaluate the association of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC) to coronary plaque composition by coronary computed tomographic angiography (CTA). METHODS: We studied 4575 individuals without known coronary artery disease not taking statin medications who underwent coronary CTA. Comparisons were made between those with high versus low LDL, HDL, TC, and non-HDL. We assessed the relationship of lipoproteins and plaques of specific composition (noncalcified [NCP], partially calcified [PCP], or calcified [CP] plaque). RESULTS: Mean age was 57 ± 11 years (55% men). In univariable analyses, high LDL, low HDL, high TC, and high non-HDL were each associated with increased prevalence of NCPs, PCPs, and CPs (P < 0.05 for all). In multivariable analyses, high non-HDL was associated with the presence of NCP (odds ratio, 1.47; 95% CI, 1.22-1.78: P < 0.001). In the further subanalysis, a weak relationship between the highest group of non HDL (≥190 mg/dL) and the presence of CP was also noted (odds ratio, 1.33; 95% CI, 1.01-1.76; P = 0.04). Further, high non-HDL was associated with increasing numbers of segments with NCP (β coefficient, 0.043; 95% CI, 0.021-0.065; P < 0.001) but not segments with PCP or CP. CONCLUSION: NCP presence and extent are associated with high non-HDL. These results suggest a relationship between lipid profile and plaque composition.
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