Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography
Authors
Ryo Nakazato ; Heidi Gransar ; Daniel S. Berman ; Victor Y. Cheng ; Fay Y. Lin ; Stephan Achenbach ; Mouaz Al-Mallah ; Matthew J. Budoff ; Filippo Cademartiri ; Tracy Q. Callister ; Hyuk-Jae Chang ; Kavitha Chinnaiyan ; Benjamin J.W. Chow ; Augustin Delago ; Martin Hadamitzky ; Joerg Hausleiter ; Philipp Kaufmann ; Erica Maffei ; Gilbert Raff ; Leslee J. Shaw ; Todd C. Villines ; Allison Dunning ; Ricardo C. Cury ; Gudrun Feuchtner ; Yong-Jin Kim ; Jonathon Leipsic ; James K. Min
Citation
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, Vol.7(2) : 83-90, 2013
BACKGROUND:
The association between lipoprotein levels and coronary plaque composition is not well understood.
OBJECTIVE:
The aim of this prospective international multicenter study of statin-naive individuals was to evaluate the association of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC) to coronary plaque composition by coronary computed tomographic angiography (CTA).
METHODS:
We studied 4575 individuals without known coronary artery disease not taking statin medications who underwent coronary CTA. Comparisons were made between those with high versus low LDL, HDL, TC, and non-HDL. We assessed the relationship of lipoproteins and plaques of specific composition (noncalcified [NCP], partially calcified [PCP], or calcified [CP] plaque).
RESULTS:
Mean age was 57 ± 11 years (55% men). In univariable analyses, high LDL, low HDL, high TC, and high non-HDL were each associated with increased prevalence of NCPs, PCPs, and CPs (P < 0.05 for all). In multivariable analyses, high non-HDL was associated with the presence of NCP (odds ratio, 1.47; 95% CI, 1.22-1.78: P < 0.001). In the further subanalysis, a weak relationship between the highest group of non HDL (≥190 mg/dL) and the presence of CP was also noted (odds ratio, 1.33; 95% CI, 1.01-1.76; P = 0.04). Further, high non-HDL was associated with increasing numbers of segments with NCP (β coefficient, 0.043; 95% CI, 0.021-0.065; P < 0.001) but not segments with PCP or CP.
CONCLUSION:
NCP presence and extent are associated with high non-HDL. These results suggest a relationship between lipid profile and plaque composition.