Cited 12 times in
Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography
DC Field | Value | Language |
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dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2014-12-18T08:52:54Z | - |
dc.date.available | 2014-12-18T08:52:54Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1934-5925 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87123 | - |
dc.description.abstract | BACKGROUND: The association between lipoprotein levels and coronary plaque composition is not well understood. OBJECTIVE: The aim of this prospective international multicenter study of statin-naive individuals was to evaluate the association of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC) to coronary plaque composition by coronary computed tomographic angiography (CTA). METHODS: We studied 4575 individuals without known coronary artery disease not taking statin medications who underwent coronary CTA. Comparisons were made between those with high versus low LDL, HDL, TC, and non-HDL. We assessed the relationship of lipoproteins and plaques of specific composition (noncalcified [NCP], partially calcified [PCP], or calcified [CP] plaque). RESULTS: Mean age was 57 ± 11 years (55% men). In univariable analyses, high LDL, low HDL, high TC, and high non-HDL were each associated with increased prevalence of NCPs, PCPs, and CPs (P < 0.05 for all). In multivariable analyses, high non-HDL was associated with the presence of NCP (odds ratio, 1.47; 95% CI, 1.22-1.78: P < 0.001). In the further subanalysis, a weak relationship between the highest group of non HDL (≥190 mg/dL) and the presence of CP was also noted (odds ratio, 1.33; 95% CI, 1.01-1.76; P = 0.04). Further, high non-HDL was associated with increasing numbers of segments with NCP (β coefficient, 0.043; 95% CI, 0.021-0.065; P < 0.001) but not segments with PCP or CP. CONCLUSION: NCP presence and extent are associated with high non-HDL. These results suggest a relationship between lipid profile and plaque composition. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Cholesterol/blood* | - |
dc.subject.MESH | Coronary Angiography/statistics & numerical data* | - |
dc.subject.MESH | Coronary Artery Disease/blood* | - |
dc.subject.MESH | Coronary Artery Disease/diagnosis* | - |
dc.subject.MESH | Coronary Artery Disease/epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Internationality | - |
dc.subject.MESH | Lipoproteins, HDL/blood* | - |
dc.subject.MESH | Lipoproteins, LDL/blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Tomography, X-Ray Computed/statistics & numerical data* | - |
dc.title | Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ryo Nakazato | - |
dc.contributor.googleauthor | Heidi Gransar | - |
dc.contributor.googleauthor | Daniel S. Berman | - |
dc.contributor.googleauthor | Victor Y. Cheng | - |
dc.contributor.googleauthor | Fay Y. Lin | - |
dc.contributor.googleauthor | Stephan Achenbach | - |
dc.contributor.googleauthor | Mouaz Al-Mallah | - |
dc.contributor.googleauthor | Matthew J. Budoff | - |
dc.contributor.googleauthor | Filippo Cademartiri | - |
dc.contributor.googleauthor | Tracy Q. Callister | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Kavitha Chinnaiyan | - |
dc.contributor.googleauthor | Benjamin J.W. Chow | - |
dc.contributor.googleauthor | Augustin Delago | - |
dc.contributor.googleauthor | Martin Hadamitzky | - |
dc.contributor.googleauthor | Joerg Hausleiter | - |
dc.contributor.googleauthor | Philipp Kaufmann | - |
dc.contributor.googleauthor | Erica Maffei | - |
dc.contributor.googleauthor | Gilbert Raff | - |
dc.contributor.googleauthor | Leslee J. Shaw | - |
dc.contributor.googleauthor | Todd C. Villines | - |
dc.contributor.googleauthor | Allison Dunning | - |
dc.contributor.googleauthor | Ricardo C. Cury | - |
dc.contributor.googleauthor | Gudrun Feuchtner | - |
dc.contributor.googleauthor | Yong-Jin Kim | - |
dc.contributor.googleauthor | Jonathon Leipsic | - |
dc.contributor.googleauthor | James K. Min | - |
dc.identifier.doi | 10.1016/j.jcct.2013.01.008 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J01291 | - |
dc.identifier.eissn | 1876-861X | - |
dc.identifier.pmid | 23622503 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1934592513000518 | - |
dc.subject.keyword | Plaque composition | - |
dc.subject.keyword | Lipid profile | - |
dc.subject.keyword | Coronary CTA | - |
dc.subject.keyword | Coronary artery disease | - |
dc.subject.keyword | Serum lipoproteins | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | Chang, Hyuck Jae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 7 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 83 | - |
dc.citation.endPage | 90 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, Vol.7(2) : 83-90, 2013 | - |
dc.identifier.rimsid | 32503 | - |
dc.type.rims | ART | - |
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