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Human liver carboxylesterase 1 outperforms alpha-fetoprotein as biomarker to discriminate hepatocellular carcinoma from other liver diseases in Korean patients

Authors
 Keun Na  ;  Seul-Ki Jeong  ;  Min Jung Lee  ;  Sang Yun Cho  ;  Sun A Kim  ;  Min-Ji Lee  ;  Si Young Song  ;  Hoguen Kim  ;  Kyung Sik Kim  ;  Hyun Woong Lee  ;  Young-Ki Paik 
Citation
 INTERNATIONAL JOURNAL OF CANCER, Vol.133(2) : 408-415, 2013 
Journal Title
 INTERNATIONAL JOURNAL OF CANCER 
ISSN
 0020-7136 
Issue Date
2013
MeSH
Adult ; Aged ; Antibodies, Monoclonal ; Area Under Curve ; Biomarkers, Tumor/metabolism* ; Carboxylic Ester Hydrolases/genetics ; Carboxylic Ester Hydrolases/metabolism* ; Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/diagnosis* ; Cohort Studies ; Female ; Humans ; Liver Diseases/blood ; Liver Diseases/diagnosis* ; Liver Neoplasms/blood ; Liver Neoplasms/diagnosis* ; Male ; Middle Aged ; Proteomics ; ROC Curve ; Sensitivity and Specificity ; alpha-Fetoproteins/metabolism*
Keywords
Adult ; Aged ; Antibodies, Monoclonal ; Area Under Curve ; Biomarkers, Tumor/metabolism* ; Carboxylic Ester Hydrolases/genetics ; Carboxylic Ester Hydrolases/metabolism* ; Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/diagnosis* ; Cohort Studies ; Female ; Humans ; Liver Diseases/blood ; Liver Diseases/diagnosis* ; Liver Neoplasms/blood ; Liver Neoplasms/diagnosis* ; Male ; Middle Aged ; Proteomics ; ROC Curve ; Sensitivity and Specificity ; alpha-Fetoproteins/metabolism*
Abstract
Although alpha-fetoprotein (AFP) is currently the major serologic biomarker for hepatocellular carcinoma (HCC), it cannot efficiently distinguish this cancer from other forms of liver disease in early diagnosis due to its low sensitivity. The aim of this study is to compare sensitivity and specificity of human carboxylesterase 1 (hCE1) and AFP biomarker. Antibody-based assays for hCE1 and AFP were used to test both biomarkers with respect to diagnostic efficiency, Youden's index and the area under the curve (AUC) through receiver operating characteristic (ROC) analysis in plasma from 208 patients with HCC (n=57), liver cirrhosis (n=27), chronic hepatitis (n=37), cholangiocarcinoma (n=22), gastric cancer (n=31) and pancreatic cancer (n=34), along with 52 healthy donors (HDs). The levels of hCE1 were significantly higher in patients with HCC than HDs and the other diseases (p<0.005), further verified by AUC values and Youden's index. In the set of HCC versus liver cirrhosis the AUC values were 0.744 (AFP), 0.918 (hCE1) and 0.938 (combination of AFP and hCE1), respectively. These results indicate that hCE1 is not only a more potent and specific marker in distinguishing cancer from liver diseases, in particular cirrhosis, but the combination of hCE1 and AFP shows also synergistic potential for greater sensitivity and specificity in early diagnosis. Therefore the antibody-based hCE1 assay appears to have high diagnostic efficiency for discriminating HCC from other forms of liver disease. It is now feasible to further validate this novel plasma-based biomarker in the large cohort we assembled.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/ijc.28020/abstract
DOI
10.1002/ijc.28020
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Sun A(김선아) ORCID logo https://orcid.org/0000-0002-7174-3640
Kim, Hogeun(김호근)
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Lee, Hyun Woong(이현웅) ORCID logo https://orcid.org/0000-0002-6958-3035
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87094
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