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Human liver carboxylesterase 1 outperforms alpha-fetoprotein as biomarker to discriminate hepatocellular carcinoma from other liver diseases in Korean patients

DC FieldValueLanguage
dc.contributor.author김경식-
dc.contributor.author김선아-
dc.contributor.author김호근-
dc.contributor.author송시영-
dc.contributor.author이현웅-
dc.date.accessioned2014-12-18T08:51:57Z-
dc.date.available2014-12-18T08:51:57Z-
dc.date.issued2013-
dc.identifier.issn0020-7136-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87094-
dc.description.abstractAlthough alpha-fetoprotein (AFP) is currently the major serologic biomarker for hepatocellular carcinoma (HCC), it cannot efficiently distinguish this cancer from other forms of liver disease in early diagnosis due to its low sensitivity. The aim of this study is to compare sensitivity and specificity of human carboxylesterase 1 (hCE1) and AFP biomarker. Antibody-based assays for hCE1 and AFP were used to test both biomarkers with respect to diagnostic efficiency, Youden's index and the area under the curve (AUC) through receiver operating characteristic (ROC) analysis in plasma from 208 patients with HCC (n=57), liver cirrhosis (n=27), chronic hepatitis (n=37), cholangiocarcinoma (n=22), gastric cancer (n=31) and pancreatic cancer (n=34), along with 52 healthy donors (HDs). The levels of hCE1 were significantly higher in patients with HCC than HDs and the other diseases (p<0.005), further verified by AUC values and Youden's index. In the set of HCC versus liver cirrhosis the AUC values were 0.744 (AFP), 0.918 (hCE1) and 0.938 (combination of AFP and hCE1), respectively. These results indicate that hCE1 is not only a more potent and specific marker in distinguishing cancer from liver diseases, in particular cirrhosis, but the combination of hCE1 and AFP shows also synergistic potential for greater sensitivity and specificity in early diagnosis. Therefore the antibody-based hCE1 assay appears to have high diagnostic efficiency for discriminating HCC from other forms of liver disease. It is now feasible to further validate this novel plasma-based biomarker in the large cohort we assembled.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntibodies, Monoclonal-
dc.subject.MESHArea Under Curve-
dc.subject.MESHBiomarkers, Tumor/metabolism*-
dc.subject.MESHCarboxylic Ester Hydrolases/genetics-
dc.subject.MESHCarboxylic Ester Hydrolases/metabolism*-
dc.subject.MESHCarcinoma, Hepatocellular/blood-
dc.subject.MESHCarcinoma, Hepatocellular/diagnosis*-
dc.subject.MESHCohort Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLiver Diseases/blood-
dc.subject.MESHLiver Diseases/diagnosis*-
dc.subject.MESHLiver Neoplasms/blood-
dc.subject.MESHLiver Neoplasms/diagnosis*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProteomics-
dc.subject.MESHROC Curve-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHalpha-Fetoproteins/metabolism*-
dc.titleHuman liver carboxylesterase 1 outperforms alpha-fetoprotein as biomarker to discriminate hepatocellular carcinoma from other liver diseases in Korean patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorKeun Na-
dc.contributor.googleauthorSeul-Ki Jeong-
dc.contributor.googleauthorMin Jung Lee-
dc.contributor.googleauthorSang Yun Cho-
dc.contributor.googleauthorSun A Kim-
dc.contributor.googleauthorMin-Ji Lee-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorHoguen Kim-
dc.contributor.googleauthorKyung Sik Kim-
dc.contributor.googleauthorHyun Woong Lee-
dc.contributor.googleauthorYoung-Ki Paik-
dc.identifier.doi10.1002/ijc.28020-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00299-
dc.contributor.localIdA00548-
dc.contributor.localIdA01183-
dc.contributor.localIdA02035-
dc.contributor.localIdA03292-
dc.relation.journalcodeJ01092-
dc.identifier.eissn1097-0215-
dc.identifier.pmid23319432-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/ijc.28020/abstract-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordAntibodies, Monoclonal-
dc.subject.keywordArea Under Curve-
dc.subject.keywordBiomarkers, Tumor/metabolism*-
dc.subject.keywordCarboxylic Ester Hydrolases/genetics-
dc.subject.keywordCarboxylic Ester Hydrolases/metabolism*-
dc.subject.keywordCarcinoma, Hepatocellular/blood-
dc.subject.keywordCarcinoma, Hepatocellular/diagnosis*-
dc.subject.keywordCohort Studies-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordLiver Diseases/blood-
dc.subject.keywordLiver Diseases/diagnosis*-
dc.subject.keywordLiver Neoplasms/blood-
dc.subject.keywordLiver Neoplasms/diagnosis*-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordProteomics-
dc.subject.keywordROC Curve-
dc.subject.keywordSensitivity and Specificity-
dc.subject.keywordalpha-Fetoproteins/metabolism*-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNameKim, Sun A-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameLee, Hyun Woong-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorKim, Sun A-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorLee, Hyun Woong-
dc.rights.accessRightsnot free-
dc.citation.volume133-
dc.citation.number2-
dc.citation.startPage408-
dc.citation.endPage415-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CANCER, Vol.133(2) : 408-415, 2013-
dc.identifier.rimsid32152-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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