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Achieving recommended low density lipoprotein cholesterol goals and the factors associated with target achievement of hypercholesterolemia patients with rosuvastatin in primary care

Authors
 Jung Ah Lee  ;  Sung Sunwoo  ;  Young Sik Kim  ;  Han Jin Oh  ;  Hee-Cheol Kang  ;  Kyung-Chae Park  ;  Dong Hyuk Sin  ;  Sang Yeoup Lee  ;  Yun Jun Yang  ;  Byung Yeon Yu  ;  Chul-Min Kim 
Citation
 CURRENT MEDICAL RESEARCH AND OPINION, Vol.29(7) : 751-760, 2013 
Journal Title
CURRENT MEDICAL RESEARCH AND OPINION
ISSN
 0300-7995 
Issue Date
2013
MeSH
Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/prevention & control ; Cholesterol, LDL/blood* ; Female ; Fluorobenzenes/therapeutic use* ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use* ; Hypercholesterolemia/drug therapy* ; Hypertension/complications ; Male ; Middle Aged ; Prospective Studies ; Pyrimidines/therapeutic use* ; Republic of Korea ; Retrospective Studies ; Risk Factors ; Rosuvastatin Calcium ; Smoking ; Sulfonamides/therapeutic use* ; Surveys and Questionnaires
Keywords
Achievement ; Framingham risk ; Primary care ; Rosuvastatin ; Target LDL-C
Abstract
OBJECTIVE:
Hypercholesterolemia is a major risk factor for cardiovascular disease and requires continuous management. The role of primary physicians in this regard is important, yet the factors associated with successful lipid lowering treatments in primary clinics have not been clearly identified. We aimed to evaluate the rate of successful hypercholesterolemia treatment in Korean primary care, and to identify the factors associated with achieving low density lipoprotein cholesterol (LDL-C) targets.
METHODS:
We prospectively recruited and retrospectively assessed 1851 Korean patients with hypercholesterolemia who visited family physicians and were prescribed rosuvastatin for the first time. LDL-C lowering targets, defined according to NCEP ATP III guidelines, were evaluated at 6 months after the first prescription. The factors associated with achieving these targets were also assessed.
RESULTS:
Overall, 87.6% of our participants attained their LDL-C goals. In multiple logistic regression analysis, good adherence to medication was strongly associated with the achievement of target LDL-C levels, whereas higher cardiovascular risk factors including diabetes (in both sexes), low high density lipoprotein, and current smoking status (in males), and hypertension (in females) were related to LDL-C target level failures.
CONCLUSION:
Our observations of the short period for hypercholesterolemia in Korean primary care has revealed that the rate of achieving target LDL-C levels was high in these patients, whereas patients at higher risk for cardiovascular disease tended to have lower LDL-C achievement outcomes. Primary care physicians should pay more attention to patients showing higher cardiovascular risk and stress the need for good adherence and management regimens in these individuals.
Full Text
http://informahealthcare.com/doi/abs/10.1185/03007995.2013.802683
DOI
10.1185/03007995.2013.802683
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hee Cheol(강희철) ORCID logo https://orcid.org/0000-0002-0309-7448
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87031
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