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Leukocyte telomere length is independently associated with gait speed in elderly women

Authors
 Jee-Yon Lee  ;  Hyo-Weon Bang  ;  Jae-Hong Ko  ;  Jung-Ha Kim  ;  Duk-Chul Lee 
Citation
 Maturitas, Vol.75(2) : 165-169, 2013 
Journal Title
 Maturitas 
ISSN
 0378-5122 
Issue Date
2013
MeSH
Aged ; Aging/genetics* ; Cross-Sectional Studies ; Fasting ; Female ; Gait/genetics* ; Humans ; Insulin/blood ; Insulin/genetics* ; Insulin Resistance/genetics* ; Leukocytes/metabolism* ; Neuropsychological Tests ; Regression Analysis ; Republic of Korea ; Telomere* ; Telomere Homeostasis ; Telomere Shortening ; Triglycerides/blood ; Triglycerides/genetics* ; Walking
Keywords
Gait speed ; Telomere length ; Aging
Abstract
OBJECTIVES: Declining gait speed is common in the elderly population and is associated with age-related conditions. Because telomere length is a reflection of aging and known to affect degenerative changes in organ systems, gait speed may be associated with telomere length. We therefore investigated the relationship between gait speed and leukocyte telomere length in elderly Korean women. STUDY DESIGN: Cross-sectional study. MAIN OUTCOME MEASURES: A total of 117 Korean elderly women participated. Metabolic variables were assessed along with gait speed calculated as walking distance (6m) divided by time. Leukocyte telomere length was measured by real-time quantitative polymerase chain reaction. RESULTS: Gait speed correlated with telomere length (r=0.38, p<0.01), fasting insulin (r=-0.19, p=0.04), homeostasis model assessment of insulin resistance index (HOMA-IR; r=-0.22, p=0.02), triglyceride (r=-0.20, p=0.03), and Korean Mini-Mental State Examination (K-MMSE; r=0.20, p=0.03) after adjusting for age. On step-wise multiple regression analysis, telomere length (β=0.35, p<0.01), K-MMSE (β=0.16, p=0.02), age (β=-0.23, p=0.01), and HOMA-IR (β=-0.19, p=0.03) were identified as independent variables associated with gait speed. CONCLUSIONS: This study suggested that telomere length may have a role in maintaining overall health status as well as preserving gait speed in the elderly population. Further studies are required to better understand the significance of our findings.
Full Text
http://www.sciencedirect.com/science/article/pii/S0378512213000819
DOI
10.1016/j.maturitas.2013.03.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87018
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