3 224

Cited 7 times in

Leukocyte telomere length is independently associated with gait speed in elderly women

 Jee-Yon Lee  ;  Hyo-Weon Bang  ;  Jae-Hong Ko  ;  Jung-Ha Kim  ;  Duk-Chul Lee 
 MATURITAS, Vol.75(2) : 165-169, 2013 
Journal Title
Issue Date
Aged ; Aging/genetics* ; Cross-Sectional Studies ; Fasting ; Female ; Gait/genetics* ; Humans ; Insulin/blood ; Insulin/genetics* ; Insulin Resistance/genetics* ; Leukocytes/metabolism* ; Neuropsychological Tests ; Regression Analysis ; Republic of Korea ; Telomere* ; Telomere Homeostasis ; Telomere Shortening ; Triglycerides/blood ; Triglycerides/genetics* ; Walking
Gait speed ; Telomere length ; Aging
OBJECTIVES: Declining gait speed is common in the elderly population and is associated with age-related conditions. Because telomere length is a reflection of aging and known to affect degenerative changes in organ systems, gait speed may be associated with telomere length. We therefore investigated the relationship between gait speed and leukocyte telomere length in elderly Korean women. STUDY DESIGN: Cross-sectional study. MAIN OUTCOME MEASURES: A total of 117 Korean elderly women participated. Metabolic variables were assessed along with gait speed calculated as walking distance (6m) divided by time. Leukocyte telomere length was measured by real-time quantitative polymerase chain reaction. RESULTS: Gait speed correlated with telomere length (r=0.38, p<0.01), fasting insulin (r=-0.19, p=0.04), homeostasis model assessment of insulin resistance index (HOMA-IR; r=-0.22, p=0.02), triglyceride (r=-0.20, p=0.03), and Korean Mini-Mental State Examination (K-MMSE; r=0.20, p=0.03) after adjusting for age. On step-wise multiple regression analysis, telomere length (β=0.35, p<0.01), K-MMSE (β=0.16, p=0.02), age (β=-0.23, p=0.01), and HOMA-IR (β=-0.19, p=0.03) were identified as independent variables associated with gait speed. CONCLUSIONS: This study suggested that telomere length may have a role in maintaining overall health status as well as preserving gait speed in the elderly population. Further studies are required to better understand the significance of our findings.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.