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Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer

Authors
 Sewha Kim  ;  Do Hee Kim  ;  Woo-Hee Jung  ;  Ja Seung Koo 
Citation
 ENDOCRINE-RELATED CANCER, Vol.20(3) : 339-348, 2013 
Journal Title
 ENDOCRINE-RELATED CANCER 
ISSN
 1351-0088 
Issue Date
2013
MeSH
Adult ; Amino Acid Transport System ASC/metabolism* ; Breast Neoplasms/classification ; Breast Neoplasms/metabolism* ; Carcinoma, Ductal, Breast/classification ; Carcinoma, Ductal, Breast/metabolism* ; Female ; Glutamate Dehydrogenase/metabolism* ; Glutaminase/metabolism* ; Glutamine/metabolism ; Humans ; Middle Aged ; Minor Histocompatibility Antigens ; Phenotype ; Tissue Array Analysis
Keywords
breast cancer ; glutamine ; metabolism
Abstract
The aim of this study was to investigate the expression of glutamine metabolism-related proteins to determine whether glutamine is metabolized differently according to breast cancer molecular subtype. We generated a tissue microarray of 702 breast cancer patients and performed immunohistochemical staining for glutamine metabolism-related proteins, including glutaminase 1 (GLS1 (GLS)), glutamate dehydrogenase (GDH (H6PD)), and amino acid transporter-2 (ASCT2 (SLC1A5)), which were separately evaluated in tumor and stroma compartments and then analyzed by breast cancer molecular subtypes. Breast cancers were classified as follows: 293 luminal A (41.7%), 166 luminal B (23.6%), 67 HER2 type (9.6%), and 176 TNBC (25.1%). HER2 type showed the highest stromal GLS1 (P=0.001), tumoral GDH (P=0.001), stromal GDH (P<0.001), and tumoral ASCT (P<0.001) expression. We identified differential expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer. The highest glutamine metabolic activity was seen in HER2-type breast cancer.
Full Text
http://erc.endocrinology-journals.org/content/20/3/339.long
DOI
10.1530/ERC-12-0398
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Jung, Woo Hee(정우희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86959
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