Cited 105 times in
Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer
DC Field | Value | Language |
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dc.contributor.author | 정우희 | - |
dc.contributor.author | 구자승 | - |
dc.date.accessioned | 2014-12-18T08:47:29Z | - |
dc.date.available | 2014-12-18T08:47:29Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1351-0088 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86959 | - |
dc.description.abstract | The aim of this study was to investigate the expression of glutamine metabolism-related proteins to determine whether glutamine is metabolized differently according to breast cancer molecular subtype. We generated a tissue microarray of 702 breast cancer patients and performed immunohistochemical staining for glutamine metabolism-related proteins, including glutaminase 1 (GLS1 (GLS)), glutamate dehydrogenase (GDH (H6PD)), and amino acid transporter-2 (ASCT2 (SLC1A5)), which were separately evaluated in tumor and stroma compartments and then analyzed by breast cancer molecular subtypes. Breast cancers were classified as follows: 293 luminal A (41.7%), 166 luminal B (23.6%), 67 HER2 type (9.6%), and 176 TNBC (25.1%). HER2 type showed the highest stromal GLS1 (P=0.001), tumoral GDH (P=0.001), stromal GDH (P<0.001), and tumoral ASCT (P<0.001) expression. We identified differential expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer. The highest glutamine metabolic activity was seen in HER2-type breast cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ENDOCRINE-RELATED CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Amino Acid Transport System ASC/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/classification | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/classification | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glutamate Dehydrogenase/metabolism* | - |
dc.subject.MESH | Glutaminase/metabolism* | - |
dc.subject.MESH | Glutamine/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Minor Histocompatibility Antigens | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Tissue Array Analysis | - |
dc.title | Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Sewha Kim | - |
dc.contributor.googleauthor | Do Hee Kim | - |
dc.contributor.googleauthor | Woo-Hee Jung | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1530/ERC-12-0398 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03671 | - |
dc.contributor.localId | A00198 | - |
dc.relation.journalcode | J00771 | - |
dc.identifier.eissn | 1479-6821 | - |
dc.identifier.pmid | 23507704 | - |
dc.identifier.url | http://erc.endocrinology-journals.org/content/20/3/339.long | - |
dc.subject.keyword | breast cancer | - |
dc.subject.keyword | glutamine | - |
dc.subject.keyword | metabolism | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 20 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 339 | - |
dc.citation.endPage | 348 | - |
dc.identifier.bibliographicCitation | ENDOCRINE-RELATED CANCER, Vol.20(3) : 339-348, 2013 | - |
dc.identifier.rimsid | 32060 | - |
dc.type.rims | ART | - |
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