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Is the GABA System Related to the Social Competence Improvement Effect of Aripiprazole? An 18F-Fluoroflumazenil PET Study

Authors
 Jung Suk Lee  ;  Jong Doo Lee  ;  Hae-Jeong Park  ;  Maeng-Keun Oh  ;  Ji Won Chun  ;  Se-Joo Kim  ;  Eosu Kim  ;  Jae-Jin Kim 
Citation
 Psychiatry Investigation, Vol.10(1) : 75-80, 2013 
Journal Title
 Psychiatry Investigation 
ISSN
 1738-3684 
Issue Date
2013
Abstract
OBJECTIVE: Patients with schizophrenia who are treated with aripiprazole experience some benefits including an improvement of social competence, but the underlying mechanism of this improvement has not been investigated yet. This study aimed to provide preliminary evidence that the GABA system may be involved in the effect of aripiprazole on social competence. METHODS: Seventeen outpatients with schizophrenia (9 taking aripiprazole and 8 taking risperidone) and 18 healthy controls underwent (18)F-fluoroflumazenil PET, and GABAA receptor binding potential was compared between the three groups. RESULTS: Voxelwise one-way ANOVA showed that GABAA receptor binding potentials in the right medial prefrontal cortex (p=0.04) and right dorsolateral prefrontal cortex (p=0.02) were significantly lower in the aripiprazole group than the risperidone group, and those in the left frontopolar cortex (p=0.03) and right premotor cortex (p=0.02) were significantly lower in the aripiprazole group than the risperidone and control groups. CONCLUSION: Our results suggest that aripiprazole administration results in increased GABA transmission in the prefrontal regions, and that these increases may be a neural basis of aripiprazole's clinical benefits on an improvement of social competence.
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DOI
10.4306/pi.2013.10.1.75
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
김세주(Kim, Se Joo) ORCID logo https://orcid.org/0000-0002-5438-8210
김어수(Kim, Eosu) ORCID logo https://orcid.org/0000-0001-9472-9465
김재진(Kim, Jae Jin) ORCID logo https://orcid.org/0000-0002-1395-4562
박해정(Park, Hae Jeong) ORCID logo https://orcid.org/0000-0002-4633-0756
이종두(Lee, Jong Doo)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86946
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