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Is the GABA System Related to the Social Competence Improvement Effect of Aripiprazole? An 18F-Fluoroflumazenil PET Study
DC Field | Value | Language |
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dc.contributor.author | 김세주 | - |
dc.contributor.author | 김어수 | - |
dc.contributor.author | 김재진 | - |
dc.contributor.author | 박해정 | - |
dc.contributor.author | 이종두 | - |
dc.date.accessioned | 2014-12-18T08:47:06Z | - |
dc.date.available | 2014-12-18T08:47:06Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1738-3684 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86946 | - |
dc.description.abstract | OBJECTIVE: Patients with schizophrenia who are treated with aripiprazole experience some benefits including an improvement of social competence, but the underlying mechanism of this improvement has not been investigated yet. This study aimed to provide preliminary evidence that the GABA system may be involved in the effect of aripiprazole on social competence. METHODS: Seventeen outpatients with schizophrenia (9 taking aripiprazole and 8 taking risperidone) and 18 healthy controls underwent (18)F-fluoroflumazenil PET, and GABAA receptor binding potential was compared between the three groups. RESULTS: Voxelwise one-way ANOVA showed that GABAA receptor binding potentials in the right medial prefrontal cortex (p=0.04) and right dorsolateral prefrontal cortex (p=0.02) were significantly lower in the aripiprazole group than the risperidone group, and those in the left frontopolar cortex (p=0.03) and right premotor cortex (p=0.02) were significantly lower in the aripiprazole group than the risperidone and control groups. CONCLUSION: Our results suggest that aripiprazole administration results in increased GABA transmission in the prefrontal regions, and that these increases may be a neural basis of aripiprazole's clinical benefits on an improvement of social competence. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PSYCHIATRY INVESTIGATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Is the GABA System Related to the Social Competence Improvement Effect of Aripiprazole? An 18F-Fluoroflumazenil PET Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Jung Suk Lee | - |
dc.contributor.googleauthor | Jong Doo Lee | - |
dc.contributor.googleauthor | Hae-Jeong Park | - |
dc.contributor.googleauthor | Maeng-Keun Oh | - |
dc.contributor.googleauthor | Ji Won Chun | - |
dc.contributor.googleauthor | Se-Joo Kim | - |
dc.contributor.googleauthor | Eosu Kim | - |
dc.contributor.googleauthor | Jae-Jin Kim | - |
dc.identifier.doi | 10.4306/pi.2013.10.1.75 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00604 | - |
dc.contributor.localId | A00686 | - |
dc.contributor.localId | A00870 | - |
dc.contributor.localId | A01730 | - |
dc.contributor.localId | A03138 | - |
dc.relation.journalcode | J02569 | - |
dc.identifier.eissn | 1976-3026 | - |
dc.identifier.pmid | 23482902 | - |
dc.subject.keyword | Aripiprazole | - |
dc.subject.keyword | Flumazenil PET | - |
dc.subject.keyword | GABAA receptor | - |
dc.subject.keyword | Prefrontal cortex | - |
dc.subject.keyword | Social competence | - |
dc.contributor.alternativeName | Kim, Se Joo | - |
dc.contributor.alternativeName | Kim, Eo Su | - |
dc.contributor.alternativeName | Kim, Jae Jin | - |
dc.contributor.alternativeName | Park, Hae Jeong | - |
dc.contributor.alternativeName | Lee, Jong Doo | - |
dc.contributor.affiliatedAuthor | Kim, Se Joo | - |
dc.contributor.affiliatedAuthor | Kim, Eo Su | - |
dc.contributor.affiliatedAuthor | Kim, Jae Jin | - |
dc.contributor.affiliatedAuthor | Park, Hae Jeong | - |
dc.contributor.affiliatedAuthor | Lee, Jong Doo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 75 | - |
dc.citation.endPage | 80 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY INVESTIGATION, Vol.10(1) : 75-80, 2013 | - |
dc.identifier.rimsid | 32052 | - |
dc.type.rims | ART | - |
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