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Predictive value of circulating interleukin-6 and heart-type fatty acid binding protein for three months clinical outcome in acute cerebral infarction: multiple blood markers profiling study

 So-Young Park  ;  Jinkwon Kim  ;  Ok-Joon Kim  ;  Jin-Kyeoung Kim  ;  Jihwan Song  ;  Dong-Ah Shin  ;  Seung-Hun Oh 
 CRITICAL CARE, Vol.17(2) : 45, 2013 
Journal Title
Issue Date
Acute Disease ; Aged ; Biomarkers/blood ; Cerebral Infarction/blood* ; Cerebral Infarction/diagnosis* ; Fatty Acid Binding Protein 3 ; Fatty Acid-Binding Proteins/blood* ; Female ; Humans ; Interleukin-6/blood* ; Male ; Middle Aged ; Predictive Value of Tests ; Time Factors ; Treatment Outcome
Infarct Volume ; Stroke Outcome ; Blood Marker ; Poor Outcome Group ; Area Under Receiver Operating Characteristic
INTRODUCTION: There is no single blood marker for predicting the prognosis in ischemic stroke. A combination of multiple blood markers may enhance the ability to predict long-term outcome following ischemic stroke. METHODS: Blood concentrations of neuronal markers (neuron-specific enolase, visinin-like protein 1, heart type fatty acid binding protein (hFABP) and neuroglobin), astroglial markers (S100B and glial fibrillary acidic protein), inflammatory markers (IL-6, TNF-α, and C-reactive protein), blood-brain barrier marker (matrix metalloproteinase 9), and haemostatic markers (D-dimer and PAI-1) were measured within 24 hours after stroke onset. The discrimination and reclassification for favorable and poor outcome were compared after adding individual or a combination of blood markers to the clinical model of stroke outcome. RESULTS: In multivariate analysis, natural log-transformed (log) IL-6 (odds ratio (OR): 1.75, 95% CI: 1.25 to 2.25, P = 0.001) and loghFABP (OR: 3.23, 95% CI: 1.44 to 7.27, P = 0.005) were independently associated with poor outcome. The addition of a single blood marker to the clinical model did not improve the discriminating ability of the clinical model of stroke outcome. However, the addition of the combination of logIL-6 and loghFABP to the clinical model showed improved discrimination (area under receiver operating characteristic (AUROC) curve: 0.939 versus 0.910, P = 0.03) and reclassification performance (net reclassification improvement index: 0.18, P = 0.005). CONCLUSIONS: A combination of circulating IL-6 and hFABP level has an additive clinical value for the prediction of stroke outcome.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Dong Ah(신동아) ORCID logo https://orcid.org/0000-0002-5225-4083
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