Cited 29 times in
Predictive value of circulating interleukin-6 and heart-type fatty acid binding protein for three months clinical outcome in acute cerebral infarction: multiple blood markers profiling study
DC Field | Value | Language |
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dc.contributor.author | 신동아 | - |
dc.date.accessioned | 2014-12-18T08:45:04Z | - |
dc.date.available | 2014-12-18T08:45:04Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1364-8535 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86885 | - |
dc.description.abstract | INTRODUCTION: There is no single blood marker for predicting the prognosis in ischemic stroke. A combination of multiple blood markers may enhance the ability to predict long-term outcome following ischemic stroke. METHODS: Blood concentrations of neuronal markers (neuron-specific enolase, visinin-like protein 1, heart type fatty acid binding protein (hFABP) and neuroglobin), astroglial markers (S100B and glial fibrillary acidic protein), inflammatory markers (IL-6, TNF-α, and C-reactive protein), blood-brain barrier marker (matrix metalloproteinase 9), and haemostatic markers (D-dimer and PAI-1) were measured within 24 hours after stroke onset. The discrimination and reclassification for favorable and poor outcome were compared after adding individual or a combination of blood markers to the clinical model of stroke outcome. RESULTS: In multivariate analysis, natural log-transformed (log) IL-6 (odds ratio (OR): 1.75, 95% CI: 1.25 to 2.25, P = 0.001) and loghFABP (OR: 3.23, 95% CI: 1.44 to 7.27, P = 0.005) were independently associated with poor outcome. The addition of a single blood marker to the clinical model did not improve the discriminating ability of the clinical model of stroke outcome. However, the addition of the combination of logIL-6 and loghFABP to the clinical model showed improved discrimination (area under receiver operating characteristic (AUROC) curve: 0.939 versus 0.910, P = 0.03) and reclassification performance (net reclassification improvement index: 0.18, P = 0.005). CONCLUSIONS: A combination of circulating IL-6 and hFABP level has an additive clinical value for the prediction of stroke outcome. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CRITICAL CARE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Cerebral Infarction/blood* | - |
dc.subject.MESH | Cerebral Infarction/diagnosis* | - |
dc.subject.MESH | Fatty Acid Binding Protein 3 | - |
dc.subject.MESH | Fatty Acid-Binding Proteins/blood* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-6/blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Predictive value of circulating interleukin-6 and heart-type fatty acid binding protein for three months clinical outcome in acute cerebral infarction: multiple blood markers profiling study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | So-Young Park | - |
dc.contributor.googleauthor | Jinkwon Kim | - |
dc.contributor.googleauthor | Ok-Joon Kim | - |
dc.contributor.googleauthor | Jin-Kyeoung Kim | - |
dc.contributor.googleauthor | Jihwan Song | - |
dc.contributor.googleauthor | Dong-Ah Shin | - |
dc.contributor.googleauthor | Seung-Hun Oh | - |
dc.identifier.doi | 10.1186/cc12564 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02092 | - |
dc.relation.journalcode | J00652 | - |
dc.identifier.eissn | 1466-609X | - |
dc.identifier.pmid | 23497639 | - |
dc.subject.keyword | Infarct Volume | - |
dc.subject.keyword | Stroke Outcome | - |
dc.subject.keyword | Blood Marker | - |
dc.subject.keyword | Poor Outcome Group | - |
dc.subject.keyword | Area Under Receiver Operating Characteristic | - |
dc.contributor.alternativeName | Shin, Dong A | - |
dc.contributor.affiliatedAuthor | Shin, Dong A | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 17 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 45 | - |
dc.identifier.bibliographicCitation | CRITICAL CARE, Vol.17(2) : 45, 2013 | - |
dc.identifier.rimsid | 29271 | - |
dc.type.rims | ART | - |
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