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Predictive value of circulating interleukin-6 and heart-type fatty acid binding protein for three months clinical outcome in acute cerebral infarction: multiple blood markers profiling study

DC FieldValueLanguage
dc.contributor.author신동아-
dc.date.accessioned2014-12-18T08:45:04Z-
dc.date.available2014-12-18T08:45:04Z-
dc.date.issued2013-
dc.identifier.issn1364-8535-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86885-
dc.description.abstractINTRODUCTION: There is no single blood marker for predicting the prognosis in ischemic stroke. A combination of multiple blood markers may enhance the ability to predict long-term outcome following ischemic stroke. METHODS: Blood concentrations of neuronal markers (neuron-specific enolase, visinin-like protein 1, heart type fatty acid binding protein (hFABP) and neuroglobin), astroglial markers (S100B and glial fibrillary acidic protein), inflammatory markers (IL-6, TNF-α, and C-reactive protein), blood-brain barrier marker (matrix metalloproteinase 9), and haemostatic markers (D-dimer and PAI-1) were measured within 24 hours after stroke onset. The discrimination and reclassification for favorable and poor outcome were compared after adding individual or a combination of blood markers to the clinical model of stroke outcome. RESULTS: In multivariate analysis, natural log-transformed (log) IL-6 (odds ratio (OR): 1.75, 95% CI: 1.25 to 2.25, P = 0.001) and loghFABP (OR: 3.23, 95% CI: 1.44 to 7.27, P = 0.005) were independently associated with poor outcome. The addition of a single blood marker to the clinical model did not improve the discriminating ability of the clinical model of stroke outcome. However, the addition of the combination of logIL-6 and loghFABP to the clinical model showed improved discrimination (area under receiver operating characteristic (AUROC) curve: 0.939 versus 0.910, P = 0.03) and reclassification performance (net reclassification improvement index: 0.18, P = 0.005). CONCLUSIONS: A combination of circulating IL-6 and hFABP level has an additive clinical value for the prediction of stroke outcome.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCritical Care-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePredictive value of circulating interleukin-6 and heart-type fatty acid binding protein for three months clinical outcome in acute cerebral infarction: multiple blood markers profiling study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorSo-Young Park-
dc.contributor.googleauthorJinkwon Kim-
dc.contributor.googleauthorOk-Joon Kim-
dc.contributor.googleauthorJin-Kyeoung Kim-
dc.contributor.googleauthorJihwan Song-
dc.contributor.googleauthorDong-Ah Shin-
dc.contributor.googleauthorSeung-Hun Oh-
dc.identifier.doi10.1186/cc12564-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02092-
dc.relation.journalcodeJ00652-
dc.contributor.alternativeNameShin, Dong A-
dc.contributor.affiliatedAuthorShin, Dong A-
dc.rights.accessRightsfree-
dc.citation.volume17-
dc.citation.number2-
dc.citation.startPage45-
dc.citation.endPage45-
dc.identifier.bibliographicCitationCritical Care, Vol.17(2) : 45-45, 2013-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)

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