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Transcriptional and epigenetic networks in the development and maturation of dendritic cells

Authors
 Hyoung-Pyo Kim  ;  Yeon-Su Lee  ;  Jong Hoon Park  ;  Young-Joon Kim 
Citation
 Epigenomics, Vol.5(2) : 195-204, 2013 
Journal Title
 Epigenomics 
ISSN
 1750-1911 
Issue Date
2013
Abstract
Dendritic cells (DCs) are professional antigen-presenting cells that provide a critical link between the innate and adaptive immune responses. The genetic program required for differentiation of DCs from their hematopoietic precursors is controlled by both cytokines and transcription factors. The signals transduced from cytokines recruit specific transcription factors, enabling the expression of a distinct transcriptome that is required for specification of different DC lineages. The establishment of a distinct transcriptome also depends on chromatin modifications associated with critical cis elements of lineage-specific genes. In this review, recent advances in the understanding of the transcriptional network governing DC lineage specification are summarized, along with current views of the dynamic DC epigenome.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86831
Full Text
http://www.futuremedicine.com/doi/abs/10.2217/epi.13.14?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed&
DOI
10.2217/epi.13.14
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실)
Yonsei Authors
김형표(Kim, Hyoung Pyo) ORCID logo https://orcid.org/0000-0003-1441-8822
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