120 181

Cited 25 times in

Clinical and economic burden of invasive pneumococcal disease in adults: a multicenter hospital-based study

 Joon Young Song  ;  Jun Yong Choi  ;  Jin Soo Lee  ;  In-Gyu Bae  ;  Young Keun Kim  ;  Jang Wook Sohn  ;  Yu Mi Jo  ;  Won Suk Choi  ;  Jacob Lee  ;  Kyung Hwa Park  ;  Woo Joo Kim  ;  Hee Jin Cheong 
 BMC INFECTIOUS DISEASES, Vol.13 : 202, 2013 
Journal Title
Issue Date
Adult ; Aged ; Anti-Bacterial Agents/pharmacology ; Female ; Health Care Costs ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Multivariate Analysis ; Pneumococcal Infections/diagnosis ; Pneumococcal Infections/economics* ; Pneumococcal Infections/epidemiology* ; Pneumococcal Infections/microbiology ; Prognosis ; Retrospective Studies ; Risk Factors ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/isolation & purification
Cost of illness ; Pneumococcal infection ; Pneumococcal vaccines ; Streptococcus pneumoniae
BACKGROUND: Streptococcus pneumoniae causes a broad spectrum of illnesses ranging from mild upper respiratory tract infections to invasive pneumococcal disease (IPD). Quantitative data on the burden of pneumococcal disease, important for the establishment of appropriate vaccination strategies, is currently lacking in adults. METHODS: This multicenter, retrospective cohort study was designed to estimate the clinical and economic burden of IPD in adults over the last decade. Data were collected from patients with IPD at 10 university hospitals in South Korea. We estimated the proportion of IPD among all hospitalized patients, the case fatality rate, and the direct medical costs of IPD. Data were further analyzed according to age and risk groups. RESULTS: During the study period, 970 patients with IPD were identified. The mean age for all patients was 60.9 years; patients aged 50-64 years (33.0%) were most numerous, followed by those aged 65-74 years (27.4%). Overall, the proportion of IPD was 0.36 cases/1000 hospitalized patients and the case fatality rate was 30.9%, which increased significantly with age (p < 0.01). The mean direct medical costs were estimated to be US $7,452 without a difference between age and risk groups. On multivariate analysis, old age, advanced ECOG performance status, bacteremic pneumonia, and nosocomial infection were independent risk factors of 30-day case fatality. CONCLUSIONS: The clinical disease burden of IPD increased significantly with age and direct medical costs from IPD were substantial, regardless of age and co-morbid conditions. The current age-based vaccination strategy appears to be appropriate.
Files in This Item:
T201301333.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.