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The effects of non-thermal atmospheric pressure plasma jet on cellular activity at SLA-treated titanium surfaces

 Eun-Jung Lee  ;  Jae-Sung Kwon  ;  Soo-Hyuk Uhm  ;  Doo-Hoon Song  ;  Yong Hee Kim  ;  Eun Ha Choi  ;  Kyoung-Nam Kim 
 CURRENT APPLIED PHYSICS, Vol.13(S1) : 36-41, 2013 
Journal Title
Issue Date
Atmospheric pressure plasma jet ; Cellular activity ; Dental implant ; Hydrophilicity ; SLA-treated titanium
Titanium (Ti) is a primary material used for dental implants, and the sandblasted, large-grit, and acid-etched (SLA) surface treatment is commonly used on titanium to promote early osseointegration. Despite their benefits, SLA-treated Ti surfaces are disadvantaged by their hydrophobic property, and much research has been performed to address this problem. In current study, we hypothesized the effects of a nitrogen-based non-thermal atmospheric pressure plasma jet (NTAPPJ) treatment on SLA-treated Ti would increase hydrophilicity and cellular activity. Samples with and without the NTAPPJ treatment were analyzed using a field emission scanning electron microscope, optical surface roughness system, X-ray photoelectron spectroscope, and water contact angle measuring system. MC3T3-E1 cells (murine osteoblastic cell line) attachments and proliferations were examined by the MTT and BrdU colorimetry assay. Cell immunofluorescent microscopic images were observed by a confocal laser scanning microscope for a morphological analysis. This study found that the nitrogen-based NTAPPJ treatment on SLA-treated Ti significantly increased the hydrophilicity and MC3T3-E1 cell attachments and proliferations. Hence, it was concluded that an additional procedure of nitrogen-based NTAPPJ treatment just prior to implantation of SLA-treated Ti into oral defect sites could improve the success of dental implant surgery.
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2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Research Center for Orofacial Hard Tissue Regeneration (구강악안면경조직재생연구센터) > 1. Journal Papers
Yonsei Authors
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Kim, Kyoung Nam(김경남)
Song, Doo Hoon(송두훈)
Uhm, Soo Hyuk(엄수혁)
Lee, Eun Jung(이은정)
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