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Microinjection of ghrelin in the nucleus accumbens core enhances locomotor activity induced by cocaine

Authors
 Ju Kyong Jang  ;  Wha Young Kim  ;  Bo Ram Cho  ;  Jung Won Lee  ;  Jeong-Hoon Kim 
Citation
 Behavioural Brain Research, Vol.248 : 7-11, 2013 
Journal Title
 Behavioural Brain Research 
ISSN
 0166-4328 
Issue Date
2013
Abstract
Ghrelin has a regulatory role not only in the rewarding aspect for feeding but also in drug addiction by interaction with mesolimbic dopaminergic pathways in the brain. Previously it has been shown that systemic ghrelin enhances cocaine-induced hyper-locomotor activity. However, it has not been determined yet what effects ghrelin may produce on cocaine-induced locomotor behavior when microinjected into the nucleus accumbens core, where cocaine actually produces its locomotor activating effects. In the present study, when rats were administered cocaine (15 mg/kg, i.p.) following a bilateral microinjection of ghrelin (0.1 or 0.5 μg/side) into the NAcc core, their locomotor activity was significantly enhanced, while these effects were inhibited by co-microinjection of ghrelin receptor antagonist (0.5 μg/side) into this site. When ghrelin alone microinjected, basal locomotor activity was unchanged. These results expand previous similar findings obtained by systemic ghrelin to more specific neuronal site, the nucleus accumbens core, and further suggest that it may work in this site to positively contribute to the expression of locomotor sensitization.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86724
Full Text
http://www.sciencedirect.com/science/article/pii/S0166432813001915
DOI
10.1016/j.bbr.2013.03.049
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실)
Yonsei Authors
김정훈(Kim, Jeong Hoon) ORCID logo https://orcid.org/0000-0001-7095-3729
김화영(Kim, Wha Young)
이정원(Lee, Jung Won)
장주경(Jang, Ju Kyong)
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